Activation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency.
Activation of factor VII during alimentary lipemia occurs in healthy adults and patients with congenital factor XII or factor XI deficiency, but not in patients with factor IX deficiency.
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健康成人和先天性因子 XII 或因子 XI 缺乏的患者会在消化性脂血症期间激活因子 VII，但因子 IX 缺乏的患者不会激活。
作者：
G. J. Miller;Janet;C.;Martin;Kostas A. Mitropoulos;M. Esnouf;Jacqueline A. Cooper;James H. Morrissey;David J. Howarth;E. G. D. Tuddenham
凝血因子VII活性（FVIIc）是冠心病的危险标志物，在餐后脂血症期间增加。因子VII激活伴随着富含磷脂酰肌醇的脂蛋白的脂解，但这种关联的性质以及是否是因果关系仍然不确定。为了探讨这个问题，四名纯合子因子XII缺乏症患者，四名完全因子Xi缺乏症患者，六名因子IX缺乏症患者，以及他们各自的年龄和性别匹配的对照组，给予两种等热量饮食方案，一种提供平均136 g脂肪，另一种提供19 g脂肪。在早餐前、午餐前195分钟和研究完成后390分钟采血。将每例受试者和匹配对照的所有样本作为一个批次进行FVIIc、活化因子VII和因子VII抗原（FVIIag）分析。在所有对照组、因子XII缺乏患者和因子XI缺乏患者中，高脂方案观察到因子VII的激活，但低脂方案未观察到。在因子IX缺乏患者的两种治疗方案中均未观察到因子VII激活，但在因子IX治疗后重复研究的1例患者中恢复了因子VII对膳食脂肪的正常餐后反应。在任何一组患者或对照组中，任何一种治疗方案餐后血浆FVIIag均未改变。因子IX显然在餐后激活因子VII中起着强制性作用，尽管其机制仍有待确定。
Factor VII activity (FVIIc), a risk marker for coronary heart disease, is increased during postprandial lipemia. Factor VII activation accompanies lipolysis of triglyceride-rich lipoproteins, but the nature of this association and whether it is causal remain uncertain. To explore this issue, four patients with homozygous factor XII deficiency, four with complete factor XI deficiency, six with factor IX deficiency, and their respective age- and sex-matched controls were given two isocaloric dietary regimens, one providing on average 136 g fat and the other 19 g fat. Blood was taken before breakfast, immediately before lunch at 195 minutes, and at completion of the study at 390 minutes. All samples for each subject and matched control were assayed as one batch for FVIIc, activated factor VII, and factor VII antigen (FVIIag). Activation of factor VII was observed with the high-fat regimen but not with the low-fat regimen in all controls, factor XII-deficient patients, and factor XI-deficient patients. No factor VII activation was observed during either regimen in factor IX-deficient patients, but a normal postprandial responsiveness of factor VII to dietary fat was restored in one patient who replicated the study after factor IX therapy. Plasma FVIIag was not altered postprandially in either regimen in any group of patients or controls. Factor IX apparently plays an obligatory role in the postprandial activation of factor VII, although the mechanism remains to be determined.
影响因子：
20.3
作者：
D. Gailani;G. Broze
通讯作者：
D. Gailani;G. Broze
因子 IXa 和 Xa 对人膀胱癌细胞上的人因子 VII 的激活。
影响因子：
20.3
作者：
Wildgoose,P;Kisiel,W
通讯作者：
Kisiel,W
丝氨酸蛋白酶对人因子 IX 的裂解和激活。
影响因子：
20.3
作者：
Enfield,DL;Thompson,AR
通讯作者：
Thompson,AR