GABAA receptor immunoreactivity in the white matter.
GABAA receptor immunoreactivity in the white matter.
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白质中的 GABAA 受体免疫反应性。
DOI：
10.1097/00001756-199202000-00012
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发表时间：
1992
期刊：
影响因子：
1.7
通讯作者：
Cynader,MS
中科院分区：
文献类型：
--
作者：
Gu,Q;Velazquez,JL;Angelides,KJ;Cynader,MS
用针对GABAA受体β1亚单位特定序列的多克隆抗体免疫组织化学方法，在猫脑白质中发现了较强的免疫反应。免疫阳性产物主要存在于神经胶质细胞，尤其是星形胶质细胞的突起。星形胶质细胞的胞体和神经元的细胞膜上也有免疫反应。白质丰富的免疫染色提示：(1)GABAA受体存在于活体胶质细胞上，(2)GABAA受体可能定位于白质的非突触膜上，(3)GABAA受体的激活可能对白质的结构和功能特性的保存有一定的营养作用。
USING immunohistochemical methods with polyclonal antibodies directed against a specific sequence of the β 1-subunit of the GABA A receptor, we found strong immunoreactivity in the white matter of cat brain. The immunopositive products were present primarily on processes of glial cells, especially astrocytes. Immunoreactivity appeared also on the cell bodies of astrocytes and on the cytoplasmic membranes of neurons. The abundant immunostaining in the white matter suggests that (1) GABA A receptors are present on glial cells in vivo,(2) GABA A receptors may be localized on non-synaptic membranes in the white matter and (3) activation of GABA A receptors may have some trophic effects on preservation of the structure and functional properties of the white matter.