The Iowa multiplex family study of schizophrenia: linkage analyses on chromosome 5.
The Iowa multiplex family study of schizophrenia: linkage analyses on chromosome 5.
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爱荷华州精神分裂症多重家族研究：5 号染色体连锁分析。
DOI：
10.1007/bf01735053
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Huether,M
中科院分区：
文献类型：
--
作者：
Crowe,RR;Black,DW;Andreasen,NC;Huether,M
We analysed six multiplex pedigrees of schizophrenia for linkage to two DNA probes mapping to the chromosome 5q11–q13 region where linkage to a gene for schizophrenia was recently reported. Analyses were conducted using three penetrance models and considering the affected state to be schizophrenia, the schizophrenia spectrum, and all psychiatric diagnoses. All analyses gave consistently negative lod scores. Although the region was not formally excluded, no evidence for linkage was found.
