Effect of intravenously administered iodipamide ethyl ester particles on rat liver morphology.
Effect of intravenously administered iodipamide ethyl ester particles on rat liver morphology.
复制标题
静脉注射碘吡酰胺乙酯颗粒对大鼠肝脏形态的影响。
DOI：
10.1097/00004424-198403000-00011
复制
发表时间：
1984
影响因子：
6.7
通讯作者：
M. Violante
中科院分区：
文献类型：
--
作者：
L. Lauteala;M. Kormano;M. Violante
用光镜和电镜观察了静脉注射碘帕胺乙酯（IDE）微粒（150 mgI/kg）对大鼠肝脏的影响。IDE颗粒在注射后几分钟内被枯否细胞吞噬。4小时后，颗粒开始溶解在枯否细胞中，引起类似水肿变性的短暂形态学改变。然而，库普弗细胞的数量似乎没有变化，并且在注射后17天超微结构正常。IDE注射后1 - 4天，肝细胞含有大脂滴。IDE注射后1周至1年，肝细胞未见变化。在整个研究过程中，贮脂细胞和内皮细胞的超微结构保持正常。
The effect of intravenously injected iodipamide ethyl ester (IDE) particles (150 mgI/kg) on the rat liver was studied by light and electron microscopy. IDE particles were phagocytized by Kupffer cells within a few minutes postinjection. After 4 hours particles began to dissolve in the Kupffer cells causing transient morphologic alterations resembling hydropic degeneration. The number of Kupffer cells seemed, however, to be unchanged and were ultrastructurally normal by 17 days postinjection. Hepatocytes contained large lipid droplets from one to four days after IDE injection. No changes were found in the hepatocytes from one week to one year after IDE injection. The fat-storing cells and endothelial cells remained ultrastructurally normal throughout the study.