Contrast improvement of confocal retinal imaging by use of phase-correcting plates
Contrast improvement of confocal retinal imaging by use of phase-correcting plates
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DOI：
10.1364/ol.27.000400
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发表时间：
2002-03-15
期刊：
影响因子：
3.6
通讯作者：
Bara, S
中科院分区：
文献类型：
--
作者：
Burns, SA;Marcos, S;Bara, S
我们开发了一种定制的扫描激光检眼镜，它使用光刻法产生的相位板来提高人类视网膜图像的对比度。我们将商用实时共聚焦显微镜的扫描引擎与定制光学器件相结合，以提供中等放大率的人类视网膜成像（3度视场）。散焦和散光用传统的试模镜片矫正。用相位板校正眼睛的高阶像差。使用633 nm激光照射视网膜。将相位板插入到光学系统中，使样本视网膜血管的对比度增加了26%。此外，视网膜的一些小特征，这是不可见的标准商业成像系统，变得可见。这些结果表明，随着用于屈光矫正的定制制造技术的快速发展，对现有眼科成像系统几乎没有增加复杂性的改进的诊断成像可能是现实的。(C)2002年美国光学学会。
We have developed a custom scanning laser ophthalmoscope that uses phase plates produced by photolithography to improve the contrast of human retinal images. We combined the scanning engine from a commercial real-time confocal microscope with custom optics to provide medium magnification imaging of the human retina (3degrees field of view). Defocus and astigmatism were corrected with conventional trial lenses. Higher-order aberrations of the eye were corrected with a phase plate. A 633-nm laser was used for illuminating the retina. Inserting the phase plate into the optical system increased the contrast of a sample retinal vessel by 26%. Additionally, a number of small features of the retina, which were not visible with standard commercial imaging systems, became visible. There results illustrate that, with the rapid development of custom fabrication techniques for refractive corrections, improved diagnostic imaging with little added complexity to existing ophthalmic imaging systems may be realistic. (C) 2002 Optical Society of America.