The origin of segmentation motor activity in the intestine.
The origin of segmentation motor activity in the intestine.
复制标题
肠道分段运动活动的起源。
DOI：
10.1038/ncomms4326
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发表时间：
2014
影响因子：
16.6
通讯作者：
Chen D
中科院分区：
文献类型：
--
作者：
Huizinga JD;Chen JH;Zhu YF;Pawelka A;McGinn RJ;Bardakjian BL;Parsons SP;Kunze WA;Wu RY;Bercik P;Khoshdel A;Chen S;Yin S;Zhang Q;Yu Y;Gao Q;Li K;Hu X;Zarate N;Collins P;Pistilli M;Ma J;Zhang R;Chen D
肠的分段运动活动促进营养物质的吸收，在世纪后期首次被描述，但其基本机制仍然知之甚少。占主导地位的理论认为交替兴奋和抑制肠神经系统。在这里，我们证明了典型的分割后，可以发生完全神经阻滞。当主导起搏点的幅度，即由与肌间神经丛相关的ICC（ICC-MP）产生的慢波，被诱导的低频节律性瞬时去极化的相位调制时，出现分段运动模式，所述诱导的低频节律性瞬时去极化由与深肌丛相关的ICC（ICC-MP）产生，导致慢波振幅的起伏和分段运动活动的有节奏的方格图案。慢波的相位振幅调制指向一个基础系统的耦合非线性振荡器起源于ICC。
The segmentation motor activity of the gut that facilitates absorption of nutrients, was first described in the late 19th century but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by ICC associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in ICC.