Preeclampsia and future cardiovascular risk.
Preeclampsia and future cardiovascular risk.
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DOI：
10.1586/14779072.5.2.283
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发表时间：
2007-03-01
影响因子：
2
通讯作者：
Magee, Laura A
中科院分区：
文献类型：
--
作者：
Newstead, J;von Dadelszen, P;Magee, Laura A
怀孕对于女性来说是一次代谢和血管“压力测试”，“失败”的女性患长期心血管并发症的风险会增加。具体而言，患有先兆子痫（和/或胎盘功能障碍的其他表现）的女性患冠心病、中风和心血管疾病的风险通常会增加。在母亲（例如高血压和蛋白尿）和胎儿（例如宫内生长受限）表现出胎盘异常（尤其是早产）的女性中，风险最高。大多数患有母体胎盘综合征的女性在怀孕后几周内就会恢复正常的临床状态，并且短期内患心血管疾病的绝对风险非常低。然而，也许胎盘复杂性妊娠为女性提供了个性化风险并采取行动的机会。需要采取行动。事实上，我们作为一个人口变得越来越重，越来越久坐，这是一个紧迫的公共卫生问题。美国心脏协会建议所有女性（即使是心血管风险较低的女性）除了戒烟之外，还应改变饮食和生活方式。考虑到女性心血管疾病的患病率和重要性，以及女性作为孩子、配偶和其他家庭成员照顾者的核心作用，从公共卫生的角度来看，让可能因复杂怀孕而动机的育龄女性参与进来将非常有价值。
Pregnancy is a metabolic and vascular 'stress test' for women and those who 'fail' are at increased risk of long-term cardiovascular complications. Specifically, women who develop preeclampsia (and/or other manifestations of placental dysfunction) are at increased risk of coronary heart disease, stroke and cardiovascular disease in general. The risk is highest among women who develop both maternal (e.g., hypertension and proteinuria) and fetal (e.g., intrauterine growth restriction) manifestations of abnormal placentation, especially with preterm delivery. Most women who develop a maternal placental syndrome return to a normal clinical state in the weeks following pregnancy and their absolute risk of cardiovascular disease in the short term is very low. However, perhaps having a placentally complicated pregnancy affords women the opportunity to personalize risk and take action. Action is needed. The fact that we, as a population, are getting heavier and more sedentary is an urgent public health issue. The American Heart Association recommends that all women (even those at low cardiovascular risk) pursue dietary and lifestyle changes, in addition to smoking cessation. Engaging women of child-bearing age who may be motivated by a complicated pregnancy would be very valuable, from a public health perspective, given the prevalence and importance of cardiovascular disease in women, and the central role of the woman as caregiver to children, spouses and other family members.