Possible misinterpretation of demarcated solid patterns of radiation fibrosis on CT scans as tumor recurrence in patients receiving hypofractionated stereotactic radiotherapy for lung cancer
Possible misinterpretation of demarcated solid patterns of radiation fibrosis on CT scans as tumor recurrence in patients receiving hypofractionated stereotactic radiotherapy for lung cancer
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DOI：
10.1016/j.ijrobp.2007.07.2383
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发表时间：
2008-03-15
影响因子：
7
通讯作者：
Kubo, Atsushi
中科院分区：
文献类型：
--
作者：
Takeda, Atsuya;Kunieda, Etsuo;Kubo, Atsushi
用途：回顾性分析附近的原发性肺癌肿瘤照射使用hypofractionated立体定向放射治疗（HSRT），以确定是否存在肿瘤recurrence.Methods和Materials的不透明的变化：经过审查委员会批准的回顾性研究，我们检查了数据从50例患者治疗的目的，为证实或高度怀疑局部周围型肺癌，并随访至少12个月。所有患者均接受50戈伊分5次（80%等剂量），并每月进行胸部X线随访，直至临床和X线结果稳定。HSRT后1个月和3个月进行随访计算机断层扫描，此后在3个月的时间间隔在头2 years.Results：中位随访时间为30.4个月（范围，12.0-73.8个月）。20例患者在中位20.7个月（范围5.9-61.4个月）时出现可疑复发肿瘤的异常阴影。只有3名患者最终发现有复发; 14名患者无复发，但怀疑有纤维化，另外3名患者的结果被认为是不确定的，因为随访时间短（
Purpose: To retrospectively analyze opacity changes near primary lung cancer tumors irradiated by using hypofractionated stereotactic radiotherapy (HSRT) to determine the presence or absence of tumor recurrence.Methods and Materials: After review-board approval for a retrospective study, we examined data from 50 patients treated with curative intent for proven or highly suspected localized peripheral-lung cancer and followed up for at least 12 months. All patients had received 50 Gy in five fractions (80% isodose) and were followed up monthly with chest X-ray until clinical and X-ray findings stabilized. Follow-up computed tomography scans were performed 1 and 3 months after HSRT and thereafter at 3-month intervals during the first 2 years.Results: Median follow-up was 30.4 months (range, 12.0-73.8 months). Abnormal opacities that were suspicious for recurrent tumor appeared in 20 patients at a median of 20.7 months (range, 5.9-61.4 months). Only 3 patients were finally found to have recurrence; 14 were recurrence free but were suspected to have fibrosis, and findings for the other 3 patients were considered equivocal because of a short follow-up period (