Clinicopathologic correlations in diabetic retinopathy. I. Histology and fluorescein angiography of microaneurysms.
Clinicopathologic correlations in diabetic retinopathy. I. Histology and fluorescein angiography of microaneurysms.
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糖尿病视网膜病变的临床病理相关性。
DOI：
10.1001/archopht.1976.03910040540013
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发表时间：
1976
影响因子：
--
通讯作者：
R. Engerman
中科院分区：
文献类型：
--
作者：
G. D. Venecia;M. Davis;R. Engerman
一名成人型糖尿病患者被诊断为左眼脉络膜恶性黑色素瘤。一个非增殖型糖尿病视网膜病变的存在，这是研究和记录的立体眼底照片和荧光素血管造影。眼球摘除术后，微血管病变与组织学相关，使用视网膜胰蛋白酶消化技术。组织学上观察到四种类型的微动脉瘤，认为它们代表了该病变发展的阶段。大多数被红细胞紧密包裹的薄壁动脉瘤没有荧光。细胞过多和厚壁的动脉瘤显示早期和晚期荧光。视网膜内微血管异常是细胞增多的扩张通道。起源于终末小动脉的那些被认为代表了新血管形成的尝试。
A patient with adult-onset diabetes mellitus was referred with a diagnosis of malignant melanoma of the choroid of the left eye. A nonproliferative type of diabetic retinopathy was present, which was studied and documented by stereoscopic fundus photographs and fluorescein angiograms. Following enucleation, the microangiopathies were correlated histologically, using the retinal trypsin digest technique. Four types of microaneurysms were seen histologically that were believed to represent stages in the development of this lesion. Most thin-walled aneurysms tightly packed with erythrocytes did not fluoresce. Aneurysms that were hypercellular and those with thick walls showed early and late fluorescence. Intraretinal microvascular abnormalities were hypercellular dilated channels. Those that take origin from terminal arterioles are believed to represent attempts at neovascularization.