Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective.
Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective.
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DOI：
10.1155/2015/852968
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发表时间：
2015
影响因子：
1.8
通讯作者：
Hyde C
中科院分区：
文献类型：
--
作者：
Castro R;Perazzo H;Grinsztejn B;Veloso VG;Hyde C
慢性丙型肝炎仍然是世界范围内慢性肝病的主要原因之一，并呈现出从轻微变化到晚期纤维化和硬化及其并发症(如肝细胞癌的发展)的不同自然病史。据估计，巴西约有145万人感染了丙型肝炎病毒，这是一个重大的公共卫生问题。本文的目的是从巴西的角度回顾慢性丙型肝炎的流行病学和管理。慢性丙型肝炎的治疗面临着挑战，因为使用非侵入性方法来分期肝纤维化作为肝活检的替代方案，以及新的无干扰素抗病毒治疗的高昂成本。此外，还讨论了丙型肝炎成本-效果分析的必要性和治疗方案的最新变化。
Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.