A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization.
A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization.
复制标题
DOI：
10.1523/eneuro.0188-22.2022
复制
发表时间：
2022-11
期刊：
影响因子：
3.4
通讯作者：
Sonuga-Barke, Edmund J. S.
中科院分区：
文献类型：
--
作者：
Mackes, Nuria K.;Mehta, Mitul A.;Beyh, Ahmad;Nkrumah, Richard O.;Golm, Dennis;Sarkar, Sagari;Fairchild, Graeme;Dell'Acqua, Flavio;Sonuga-Barke, Edmund J. S.
关键词：
童年早期的忽视会影响一生中的大脑发育。使用基于体素的方法，我们最近报道，儿童早期严重且有时间限制的机构剥夺与20年后成年后大脑总体积的大幅减少有关。在这里，我们利用基于扩散的技术，将这一分析扩展到探索与剥夺相关的区域白质体积和微结构组织。对59名年轻人的扩散加权成像数据进行了张量形态计量分析和声道成像，这些年轻人在英国家庭中度过了3至41个月的严重剥夺罗马尼亚机构的20世纪80年代，以及20名年龄匹配的非剥夺年龄的英国对照组。与总体积无关，机构性剥夺与一系列白质束局部区域的体积较小有关，这些白质束包括(1)长距离联系纤维，如双侧下纵束(ILF)、双侧额枕下束(IFOF)、左上纵束(SLF)和左侧弓状束；(2)边缘环路的束，包括穹隆和扣带；(3)皮质脊髓束受影响特别大的投射纤维。示踪分析没有发现任何纤维束在阻碍调制取向各向异性(HMOA)、分数各向异性(FA)或平均扩散率(MD)方面的微结构组织改变的证据。我们为早期忽视对大脑发育的影响及其在成年后的持久性提供了进一步的证据，尽管成功地采用了多年的环境丰富。局限性白质效应似乎仅限于体积变化，微结构组织不受影响。
Early childhood neglect can impact brain development across the lifespan. Using voxel-based approaches we recently reported that severe and time-limited institutional deprivation in early childhood was linked to substantial reductions in total brain volume in adulthood, >20 years later. Here, we extend this analysis to explore deprivation-related regional white matter volume and microstructural organization using diffusion-based techniques. A combination of tensor-based morphometry (TBM) analysis and tractography was conducted on diffusion-weighted imaging (DWI) data from 59 young adults who spent between 3 and 41 months in the severely depriving Romanian institutions of the 1980s before being adopted into United Kingdom families, and 20 nondeprived age-matched United Kingdom controls. Independent of total volume, institutional deprivation was associated with smaller volumes in localized regions across a range of white matter tracts including (1) long-ranging association fibers such as bilateral inferior longitudinal fasciculus (ILF), bilateral inferior fronto-occipital fasciculus (IFOF), left superior longitudinal fasciculi (SLFs), and left arcuate fasciculus; (2) tracts of the limbic circuitry including fornix and cingulum; and (3) projection fibers with the corticospinal tract particularly affected. Tractographic analysis found no evidence of altered microstructural organization of any tract in terms of hindrance modulated orientational anisotropy (HMOA), fractional anisotropy (FA), or mean diffusivity (MD). We provide further evidence for the effects of early neglect on brain development and their persistence in adulthood despite many years of environmental enrichment associated with successful adoption. Localized white matter effects appear limited to volumetric changes with microstructural organization unaffected.