B-CELLS EXPRESSING CD5 ARE INCREASED IN SJOGRENS SYNDROME
B-CELLS EXPRESSING CD5 ARE INCREASED IN SJOGRENS SYNDROME
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DOI：
10.1002/art.1780310509
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发表时间：
1988-05-01
影响因子：
--
通讯作者：
TALAL, N
中科院分区：
文献类型：
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作者：
DAUPHINEE, M;TOVAR, Z;TALAL, N
在这项对表达CD 5（Leu-1）细胞表面标志物的B细胞的研究中，我们发现在19例原发性干燥综合征（SS）患者中有13例（68%）以及类风湿性关节炎患者中这些细胞的数量增加。显示CD 5表达增加的B细胞百分比在SS患者中为46%，在类风湿性关节炎患者中为47%，在系统性红斑狼疮患者中为24%，在正常受试者中为26%。在2年的时间里，除了2名需要类固醇治疗或联合化疗和放疗的恶性淋巴瘤患者外，几名患者的B细胞上的CD 5表达是稳定的。这两名患者均获得临床缓解，其CD 5 + B细胞水平恢复正常。第一个病人有SS/系统性红斑狼疮重叠的临床表现，与多克隆B细胞活化和响应于植物血凝素刺激的白细胞介素-2的产生减少有关。这些细胞免疫异常在皮质类固醇治疗后恢复正常。我们的观察表明，CD 5 + B细胞异常和疾病活动之间的关系。结果进行了讨论有关的免疫调节特性的CD 5 + B细胞在自身免疫小鼠和恶性淋巴瘤的特征性易感性SS患者之间。
In this investigation of B cells expressing the CD5 (Leu-1) cell surface marker, we found increased number of these cells in 13 of 19 patients with primary Sjogren''s syndrome (SS) (68%), as well as in the rheumatoid arthritis patients. The percentage of B cells that demonstrated increased expression of CD5 was 46% in SS patients, 47% in rheumatoid arthritis patients, 24% in systemic lupus erythematosus patients, and 26% in normal subjects. Over a 2-year period, CD5 expression on B cells was a stable finding in several patients, except for 2 who required either steroid therapy or combined chemotherapy and irradiation for malignant lymphoma. Both of these patients had clinical remissions and their levels of CD5+ B cells returned to normal. The first patient had a clinical picture of SS/systemic lupus erythematosus overlap, associated with polyclonal B cell activation and decreased production of interleukin-2 in response to stimulation with phytohemagglutinin. These cellular immune abnormalities returned to normal after the institution of corticosteroids. Our observations suggest a relationship between the CD5+ B cell abnormality and disease activity. The results are discussed in relation to immunoregulatory properties of CD5+ B cells in autoimmune mice and the characteristic predisposition to malignant lymphoma among SS patients.