A simplified spin and gradient echo approach for brain tumor perfusion imaging.
A simplified spin and gradient echo approach for brain tumor perfusion imaging.
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DOI：
10.1002/mrm.25591
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发表时间：
2016-01
影响因子：
3.3
通讯作者：
Quarles CC
中科院分区：
文献类型：
--
作者：
Stokes AM;Quarles CC
提出了一种基于自旋和梯度回波（SAGE）的DSC-MRI数据的简化采集和分析方法，该方法不受造影剂T1泄漏效应的影响。使用五回波SAGE序列获取大鼠C6肿瘤（n=7）的DSC-MRI数据。对所有回波进行非线性拟合，以获得T1不敏感的ΔR2* 和ΔR2时间序列。简化的方法包括两个梯度回波和一个自旋回波，还用于分析计算T1不敏感的ΔR2*（使用两个梯度回波）和ΔR2（使用所有三个回波）。比较了每种方法得出的血流量、血容量和血管尺寸值。在所有情况下，与未校正的单回波数据相比，五回波和简化SAGE ΔR2* 和ΔR2具有良好的一致性，并显示出显著的T1泄漏校正。两种方法之间推导出的血容量、血流量和血管尺寸的血流动力学参数无显著差异。所提出的简化SAGE技术能够采集针对T1泄漏效应校正的梯度和自旋回波DSC-MRI数据，产生与五回波SAGE一致的参数，并且不需要非线性拟合来提取ΔR2* 和ΔR2时间序列。
A simplified acquisition and analysis approach for spin- and gradient-echo (SAGE) based DSC-MRI data that is free of contrast agent T1 leakage effects is proposed. A five-echo SAGE sequence was used to acquire DSC-MRI data in rat C6 tumors (n=7). Non-linear fitting of all echoes was performed to obtain T1-insensitive ΔR2* and ΔR2 time series. The simplified approach, which includes two gradient echoes and one spin echo, was also used to analytically compute T1-insensitive ΔR2*, using the two gradient echoes, and ΔR2, using all three echoes. The blood flow, blood volume and vessel size values derived from each method were compared. In all cases, the five-echo and simplified SAGE ΔR2* and ΔR2 were in excellent agreement and demonstrated significant T1-leakage correction compared to the uncorrected single-echo data. The derived hemodynamic parameters for blood volume, blood flow and vessel size were not significantly different between the two methods. The proposed simplified SAGE technique enables the acquisition of gradient and spin echo DSC-MRI data corrected for T1 leakage effects, yields parameters that are in agreement with the five echo SAGE, and does not require non-linear fitting to extract ΔR2* and ΔR2 time series.