Inhibitory effect of human follicular fluid upon the maturation of porcine oocytes in culture.
Inhibitory effect of human follicular fluid upon the maturation of porcine oocytes in culture.
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人卵泡液对培养的猪卵母细胞成熟的抑制作用。
DOI：
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发表时间：
1978
影响因子：
5.8
通讯作者：
C. Channing
中科院分区：
文献类型：
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作者：
T. Hillensjö;S. K. Batta;A. Schwartz;A. C. Wentz;J. Sulewski;C. Channing
人卵泡液（hFFl）取自剖腹手术获得的人卵巢卵泡（5- 15mm）。在培养基中添加天然hFFl或其低分子量部分，可抑制猪卵母细胞的自发成熟。hFFl对孕酮的分泌也有抑制作用。该结果扩展了早期在其他哺乳动物物种中的观察结果，表明在人类中，也有一种特定的卵母细胞成熟抑制剂负责使卵母细胞处于减数分裂停滞状态。
Human follicular fluid (hFFl) was harvested from follicles (5-15 mm) of human ovaries obtained at laparotomy. Addition of native hFFl, or a low molecular weight fraction of it, to the culture medium was found to inhibit the spontaneous maturation of cumulus-enclosed porcine oocytes. It was also found that hFFl inhibited progesterone secretion by the cumulus cells. The results extend earlier observations in other mammalian species, indicating that in the human, also, a specific oocyte maturation inhibitor is responsible for keeping the oocyte in meiotic arrest.