Acute myeloid leukemia in the older adults.
Acute myeloid leukemia in the older adults.
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DOI：
10.1016/j.lrr.2016.06.001
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发表时间：
2016
影响因子：
--
通讯作者：
Ramos F
中科院分区：
文献类型：
--
作者：
Almeida AM;Ramos F
AML 是一种侵袭性血液恶性肿瘤，在老年人中发病率最高。老年人 AML 的不良特征以及他们经常出现的虚弱和合并症，使其治疗成为特别困难的治疗挑战。在这种情况下，使用经过验证的工具仔细评估患者以及疾病相关的预后特征非常重要。身体健康的患者应考虑接受治疗，例如骨髓移植，而低强度的选择可能更适合虚弱的患者。在此，我们回顾如何评估老年 AML 患者以及可供他们选择的治疗方案。对于患有 AML 的老年人来说，治疗选择仍然有限。目前，只有一小部分老年 AML 患者接受 HCT。老年人 AML 的独特特征促使我们对这些患者采取新的治疗方法。低强度选择可能更适合虚弱的患者。老年评估和社会支持至关重要。
AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult therapeutic challenge. In this context, it is important to assess carefully patient- as well as disease-associated prognostic features with validated tools. The fittest patients should be considered for curative therapy, such as bone marrow transplantation, whereas low intensity options may be more appropriate for frail patients. Here we review how to assess patients with elderly AML and the treatments options available for them. Treatment options remain limited for older adults with AML. Nowadays only a tiny proportion of elderly patients with AML undergo HCT. The unique features of AML in the elderly urge a fresh approach to these patients. Low intensity options may be more appropriate for frail patients. Geriatric assessment and social support are critical.