Grafting antibacterial polymer brushes from titanium surface via polydopamine chemistry and activators regenerated by electron transfer ATRP
Grafting antibacterial polymer brushes from titanium surface via polydopamine chemistry and activators regenerated by electron transfer ATRP
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通过聚多巴胺化学和电子转移 ATRP 再生的活化剂从钛表面接枝抗菌聚合物刷
DOI：
10.1016/j.reactfunctpolym.2019.04.002
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发表时间：
2019-07-01
影响因子：
5.1
通讯作者：
Ge, Xiangcai
中科院分区：
文献类型：
--
作者：
Wang, Shuangshuang;Song, Jixuan;Ge, Xiangcai
本文介绍了一种环境友好的、方便的方法来赋予钛表面抗菌功能。首先将聚多巴胺（PDA）沉积到碱活化的Ti基底上。然后将2-溴异丁酰溴（BIBB）固定在PDA涂层钛表面。最后，利用电子转移原子转移自由基聚合（ARGET-ATRP）再生的活化剂，将BIBB功能化的Ti引发甲基丙烯酸N，N-二乙氨基乙酯（DEAEMA）和甲基丙烯酸N，N-二甲氨基乙酯（DMAEMA）聚合，得到Ti@PDA-g-聚合物刷。在钛表面制备的PDEAEMA和PDMAEMA刷随后将通过使用1-溴辛烷季铵化，这将赋予所获得的产物以季铵基团。用X射线光电子能谱（XPS）对功能化Ti的表面组成进行了表征。通过静态水接触角测量确定功能化Ti表面的亲水/疏水性质，并通过扫描电子显微镜（SEM）表征其形貌。采用活/死细胞染色法对PDEAEMA和PDMAEMA涂层钛的抗菌性能进行了评价。结果表明，季铵化聚合物修饰钛对土壤中的大肠杆菌具有良好的杀菌效果。coli），对大肠杆菌的抑菌率为100%。大肠杆菌的分离率接近90%。
An environmentally benign and convenient approach to impart titanium (Ti) surfaces with antibacterial functionalities was described in this work. Polydopamine (PDA) was first deposited onto an alkali activated Ti substrates. Then 2-bromoisobutyryl bromide (BIBB) was immobilized on the surface of PDA coated Ti. Finally, the BIBB functionalized Ti initiated the polymerization of N, N-diethylaminoethyl methacrylate (DEAEMA) and N, N-dimethylaminoethyl methacrylate (DMAEMA) to obtain Ti@PDA-g-polymer brushes by activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP). The prepared PDEAEMA and PDMAEMA brushes on Ti surfaces would be subsequently quatemized by using 1-bromooctane, which would impart the obtained products with quaternary ammonium groups. The surface compositions of the functionalized Ti were characterized by X-ray photoelectron spectroscopy (XPS). The hydrophilic/hydrophobic properties of the functionalized Ti surfaces were determined by static water contact angle measurements, and morphologies were characterized by scanning electron microscope (SEM). Antibacterial abilities of quaternized PDEAEMA and PDMAEMA coated Ti were evaluated by the contact killing test, in which live/dead cell staining method was employed. The results showed that the quatemized polymer decorated Ti exhibited good bactericidal effects against Escherichi coli (E. coli), and its inhibition rate of E. coli were observed to be nearly 90%.