Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma.
Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma.
复制标题
DOI：
10.1002/ijc.25609
复制
发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Spagnoli, Giulio C.
中科院分区：
文献类型：
--
作者：
Sconocchia, Giuseppe;Zlobec, Inti;Lugli, Alessandro;Calabrese, Diego;Iezzi, Giandomenica;Karamitopoulou, Eva;Patsouris, Efstratios S.;Peros, George;Horcic, Milo;Tornillo, Luigi;Zuber, Markus;Droeser, Raoul;Muraro, Manuele G.;Mengus, Chantal;Oertli, Daniel;Ferrone, Soldano;Terracciano, Luigi;Spagnoli, Giulio C.
巨噬细胞和自然杀伤（NK）细胞浸润在结直肠癌（CRC）微环境中的预后意义尚不清楚。我们使用两个独立的组织微阵列和免疫组织化学研究了超过1，600例CRC中的CRC先天性炎症浸润。采用Kaplan-Meier法和考克斯比例风险回归分析在多变量环境中评估生存时间。斯皮尔曼等级相关检验巨噬细胞和淋巴细胞浸润之间的关联。巴塞尔研究包括1，400多个CRC。CD 16+细胞浸润水平与CD 3+、CD 8+淋巴细胞浸润水平相关，而与NK细胞浸润水平无相关性。高CD 16+细胞浸润（评分2）的患者比低（评分1）浸润的患者存活时间更长（p = 0.008），而CD 56+（p = 0.264）或CD 57+细胞（p = 0.583）浸润评分1或2的患者之间未检测到生存差异。CD 16+浸润与生存期改善相关，即使在调整已知的预后因素（包括pT、pN、分级、血管浸润、肿瘤生长和年龄）后也是如此[（p = 0.001：HR（95% CI）= 0.71（0.6-0.9）]。这些效应与CD 8+淋巴细胞浸润[（p = 0.036：HR（95% CI）= 0.81（0.7-0.9）]和转移灶的存在[（p = 0.002：HR（95% CI）= 0.43（0.3-0.7）]无关。表型研究确定CD 16+为CD 45 + CD 33 + CD 11b + CD 11 c+，但CD 64 − HLA-DR-髓样细胞。在雅典大学进行的一项研究独立验证了CD 16+细胞浸润的有益作用，证实CD 16评分为2的患者比评分为1的CRC患者存活时间更长（p = 0.011）。因此，CD 16+细胞浸润代表了CRC的一个新的有利预后因素。
The prognostic significance of macrophage and natural killer (NK) cell infiltration in colorectal carcinoma (CRC) microenvironment is unclear. We investigated the CRC innate inflammatory infiltrate in over 1,600 CRC using two independent tissue microarrays and immunohistochemistry. Survival time was assessed using the Kaplan–Meier method and Cox proportional hazards regression analysis in a multivariable setting. Spearman's rank correlation tested the association between macrophage and lymphocyte infiltration. The Basel study included over 1,400 CRCs. The level of CD16+ cell infiltration correlated with that of CD3+ and CD8+ lymphocytes but not with NK cell infiltration. Patients with high CD16+ cell infiltration (score 2) survived longer than patients with low (score 1) infiltration (p = 0.008), while no survival difference between patients with score 1 or 2 for CD56+ (p = 0.264) or CD57+ cell (p = 0.583) infiltration was detected. CD16+ infiltrate was associated with improved survival even after adjusting for known prognostic factors including pT, pN, grade, vascular invasion, tumor growth and age [(p = 0.001: HR (95% CI) = 0.71 (0.6–0.9)]. These effects were independent from CD8+ lymphocyte infiltration [(p = 0.036: HR (95% CI) = 0.81 (0.7–0.9)] and presence of metastases [(p = 0.002: HR (95% CI) = 0.43 (0.3–0.7)]. Phenotypic studies identified CD16+ as CD45+CD33+CD11b+CD11c+ but CD64− HLA-DR-myeloid cells. Beneficial effects of CD16+ cell infiltration were independently validated by a study carried out at the University of Athens confirming that patients with CD16 score 2 survived longer than patients with score 1 CRCs (p = 0.011). Thus, CD16+ cell infiltration represents a novel favorable prognostic factor in CRC.
登录
查看更多内容
影响因子：
20.3
作者：
MacDonald, KPA;Munster, DJ;Hart, DNJ
通讯作者：
Hart, DNJ
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
影响因子：
45.3
作者：
Mamounas, E;Wieand, S;Rockette, H
通讯作者：
Rockette, H
影响因子：
45.3
作者：
Allegra, Carmen J.;Jessup, J. Milburn;Schilsky, Richard L.
通讯作者：
Schilsky, Richard L.
影响因子：
158.5
作者：
Hurwitz, H;Fehrenbacher, L;Kabbinavar, F
通讯作者：
Kabbinavar, F