Cognitive performance and the thymus among HIV-infected subjects receiving HAART.
Cognitive performance and the thymus among HIV-infected subjects receiving HAART.
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DOI：
10.2147/btt.s1753
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发表时间：
2008-06
期刊：
影响因子：
--
通讯作者：
Fishman J
中科院分区：
文献类型：
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作者：
Miguez-Burbano MJ;Lewis JE;Moreno J;Fishman J
评估在人类免疫缺陷病毒（HIV）阳性个体中广泛存在的酒精使用对高活性抗逆转录病毒治疗（HAART）相关免疫和认知改善的影响以及这两种反应之间的关系。在一项病例对照的纵向研究中，在基线和治疗6个月后，对HIV+和HIV-对照的胸腺体积、认知和免疫反应进行了评估。使用HIV痴呆评分（HDS）和加州语言学习测试（CVLT）评估认知表现。在HAART之前，胸腺体积从2.7到29.3 cm3（11±7.2 cm3）变化很大。基线胸腺容量与患者饮酒年数呈显著负相关（r2 = 0.207, p < 0.01）， hiv感染者（r2 = 0.37, p = 0.03）和非hiv感染者（r2 = 0.8, p < 0.01）的HDS和CVLT评分也呈显著负相关。与胸腺体积较大的hiv感染者相比，胸腺体积较小的hiv感染者得分在痴呆范围内（7±2.7比12±2.3,p = 0.005）。HAART后，轻度/中度饮酒者胸腺大小是重度饮酒者的两倍（14.8±10.4 cm3 vs. 6.9±3.3 cm3）。haart相关的胸腺体积增加似乎受到酒精消耗的负面影响，并与他们的认知状态显著相关。这一结果可能具有重要的临床意义。
To evaluate the impact of alcohol use, which is widespread in human immunodeficiency virus (HIV)+ individuals, on highly active antiretroviral therapy (HAART)-associated immune and cognitive improvements and the relationship between those two responses. In a case-control longitudinal study, thymic volume, cognition, and immune responses were evaluated at baseline and after 6 months therapy in HIV+ and HIV- controls. Cognitive performance was evaluated using the HIV Dementia Score (HDS) and the California Verbal Learning Test (CVLT). Prior to HAART, thymic volume varied considerably from 2.7 to 29.3 cm3 (11 ± 7.2 cm3). Thymic volume at baseline showed a significantly inverse correlation with the patient’s number of years of drinking (r2 = 0.207; p < 0.01), as well as HDS and the CVLT scores in both HIV-infected (r2 = 0.37, p = 0.03) and noninfected (r2 = 0.8, p < 0.01). HIV-infected individuals with a small thymic volume scored in the demented range, as compared with those with a larger thymus (7 ± 2.7 vs. 12 ± 2.3, p = 0.005). After HAART, light/moderate drinkers exhibited thymus size twice that of heavy drinkers (14.8 ± 10.4 vs. 6.9 ± 3.3 cm3). HAART-associated increases of thymus volume appear to be negatively affected by alcohol consumption and significantly related to their cognitive status. This result could have important clinical implications.