Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia
Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia
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DOI：
10.1016/s0006-3223(98)00373-4
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发表时间：
1999-10-01
影响因子：
10.6
通讯作者：
Catts, SV
中科院分区：
文献类型：
--
作者：
Levitan, C;Ward, PB;Catts, SV
背景：以前的研究已经报道了幻听的严重程度与语言处理所涉及的颞叶皮质区域的缩小之间的显著相关性，这表明了一种新的关系。本研究使用高分辨率磁共振成像(MRI)扫描，并通过二分听任务(DLT)评估功能偏侧化，以扩展这些发现。方法：30名有幻听病史的精神分裂症患者参与研究。所有人都完全是右撇子。在研究进行时，有11名受试者正在产生幻觉。获得体积T1加权MRI扫描，并使用Brain包手动追踪感兴趣区(Andreasen等，1993)。计算全脑、双侧颞叶和前上回的体积。受试者完成了双耳辅音-元音DLT。结果：幻觉体验的严重程度与左侧颞前上回体积的缩小显著相关。目前的幻觉者在DLT上表现出右耳优势的下降。结论：结果表明，听觉幻觉被语言相关神经网络中的特征样功能障碍所取代，其中上颞叶皮质是其中的一个组成部分。这一发现也与幻听病因中异常偏侧的理论相一致。生物精神病学1999；46：955-962(C)1999生物精神病学学会。
Background: Previous studies have reported significant correlations, indicating an emerging relationship, between severity of auditory hallucinations and reduced size of temporal lobe cortical regions implicated in language processing. The present study used high-resolution magnetic resonance imaging (MRI) scanning, along with assessment of functional lateralization via a dichotic listening task (DLT), to extend these findings.Methods: Thirty patients with schizophrenia and a history of auditory hallucinations participated in the study. All were completely right-handed. Eleven subjects were currently hallucinating at the time of the study. Volumetric T1-weighted MRI scans were obtained and regions of interest were manually traced using the BRAINS package (Andreasen et al 1993). Whole brain, bilateral temporal lobe, and anterior superior temporal gyrus volumes were calculated. Subjects completed a binaural consonant-vowel DLT.Results: Increased severity of hallucinatory experience was significantly associated with smaller left anterior superior temporal gyrus volumes. Current hallucinators demonstrated a reduction in right ear advantage on the DLT.Conclusions: The results suggest that auditory hallucinations are subserved by a trait-like dysfunction in language-related neural networks, of which the superior temporal cortex forms one component. The findings are also consistent with theories proposing abnormal lateralization in the etiology of auditory hallucinations. Biol Psychiatry 1999;46:955-962 (C) 1999 Society of Biological Psychiatry.