Role of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and Cancer.
Role of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and Cancer.
复制标题
细胞因子诱导的糖基化变化在调节炎症性疾病和癌症中细胞相互作用和细胞信号传导中的作用。
DOI：
10.3390/cells5040043
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发表时间：
2016-11-29
期刊：
影响因子：
6
通讯作者：
Delannoy P
中科院分区：
文献类型：
--
作者：
Dewald JH;Colomb F;Bobowski-Gerard M;Groux-Degroote S;Delannoy P
Glycosylation is one of the most important modifications of proteins and lipids, and cell surface glycoconjugates are thought to play important roles in a variety of biological functions including cell-cell and cell-substrate interactions, bacterial adhesion, cell immunogenicity and cell signaling. Alterations of glycosylation are observed in number of diseases such as cancer and chronic inflammation. In that context, pro-inflammatory cytokines have been shown to modulate cell surface glycosylation by regulating the expression of glycosyltransferases involved in the biosynthesis of carbohydrate chains. These changes in cell surface glycosylation are also known to regulate cell signaling and could contribute to disease pathogenesis. This review summarizes our current knowledge of the glycosylation changes induced by pro-inflammatory cytokines, with a particular focus on cancer and cystic fibrosis, and their consequences on cell interactions and signaling.
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影响因子：
3.7
作者：
Bobowski, Marie;Vincent, Audrey;Delannoy, Philippe
通讯作者：
Delannoy, Philippe
影响因子：
3.9
作者：
Colomb, Florent;Krzewinski-Recchi, Marie-Ange;Groux-Degroote, Sophie
通讯作者：
Groux-Degroote, Sophie
肠道粘蛋白型 O-糖基化缺陷导致小鼠自发性结肠炎相关癌症。
影响因子：
29.4
作者：
Bergstrom K;Liu X;Zhao Y;Gao N;Wu Q;Song K;Cui Y;Li Y;McDaniel JM;McGee S;Chen W;Huycke MM;Houchen CW;Zenewicz LA;West CM;Chen H;Braun J;Fu J;Xia L
通讯作者：
Xia L
影响因子：
24.5
作者：
Bodger, K.;Halfvarson, J.;Rhodes, J. M.
通讯作者：
Rhodes, J. M.
影响因子：
3.9
作者：
Birklé, S;Zeng, G;Aubry, J
通讯作者：
Aubry, J