Prevalence of Protein C Deficiency in Patients with Cardiovascular Problems in Japan
Prevalence of Protein C Deficiency in Patients with Cardiovascular Problems in Japan
复制标题
日本心血管疾病患者蛋白质 C 缺乏症的患病率
DOI：
10.1055/s-0037-1614499
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发表时间：
1999
影响因子：
6.7
通讯作者：
T. Miyata
中科院分区：
文献类型：
--
作者：
T. Sakata;Y. Katayama;T. Matsuyama;H. Kato;T. Miyata
我们的结果与Halbmayer等人的结果相当。(2)17%的青少年卒中患者出现APC-R。然而，这一比例明显高于库什曼等人观察到的7%。(1)特发性动脉血栓形成患者。这种差异可能是因为在我们的研究中纳入了较低年龄组(40岁)和非栓塞性脑动脉梗塞病例，而在他的研究中纳入了较高年龄组(55岁)和多种动脉疾病。Halbmayer等人随后的研究使用改进的APC测试，在他们之前的研究中没有用经典方法证实高APC-R。这归因于大量的分析前因素。相反，在我们的研究中，所有用Dahlbäck方法检测APC-R的病例，改良试验也是阳性的。这可能是因为在我们的研究中严格排除了狼疮抗凝剂或口服抗凝剂治疗的患者，从而减少了其假阳性。此外，被认为与FV Leiden基因分型一样特异的改良试验在经典APC试验结果与之接近的患者中检测到了APC耐药性。这可能表明，与经典的APC测试相比，改进的APC测试具有额外的诊断优势，特别是在影响它的分析前因素被最小化的情况下。因此，APC抵抗可能在动脉血栓形成中具有血栓前的潜在作用，因此必须进行鉴定，以便在这些患者中进行辅助预防性口服抗凝治疗。然而，因子V Leiden突变在它们中的遗传鉴定还需要进一步的研究。Sujata Mohanty，Renu Saxena，Madhuri Behari 2，来自印度新德里全印度医学研究所神经科学系血液科
Our results are comparable to those of Halbmayer et al. (2) where APC-R was observed in 17% of patients with juvenile strokes. However, it is significantly higher than the 7% observed by Cushman et al. (1) in patients with idiopathic arterial thrombosis. This difference may be due to inclusion of the lower age group (<40 years) and only non embolic cerebral arterial infarct cases in our study in contrast to higher age (<55 years) and a large variety of arterial diseases in his study. Subsequent studies by Halbmayer et al., using the modified APC test, didn’t confirm the high APC-R by classical method in their previous study. This was attributed to large number of pre-analytical factors. On the contrary, in our study all cases which had APC-R by Dahlbäck’s method were observed to be positive by the modified test as well. This may be because of strict exclusion of patients with lupus anticoagulant, or oral anticoagulant therapy in our study, thereby reducing its false positivity. Moreover, the modified test, which is considered as specific as genotyping of FV Leiden detected APC resistance in patients with borderline results of classical APC test. This might suggest an added diagnostic advantage of the modified over the classical APC test especially when the preanalytic factors affecting it are minimised. It is thus concluded that APC resistance may have a prethrombotic potential in arterial thrombosis and must be identified to enable administration of adjunct prophylactic oral anticoagulant therapy in these patients. However further studies on genetic identification of factor V Leiden mutation in them are required. Sujata Mohanty, Renu Saxena, Madhuri Behari 2 From the Department of Haematology, Department of Neurosciences, All India Institute of Medical Sciences, New Delhi, India
影响因子：
158.5
作者：
MILETICH, J;SHERMAN, L;BROZE, G
通讯作者：
BROZE, G