Quantitative Control of Neuron Adhesion at a Neural Interface Using a Conducting Polymer Composite with Low Electrical Impedance
Quantitative Control of Neuron Adhesion at a Neural Interface Using a Conducting Polymer Composite with Low Electrical Impedance
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DOI：
10.1021/am1008369
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发表时间：
2011-01-01
影响因子：
9.5
通讯作者：
Pamore, G. Tayhas R.
中科院分区：
文献类型：
--
作者：
Kim, Sung Yeol;Kim, Kwang-Min;Pamore, G. Tayhas R.
在神经接口的应用中，定制电极上的细胞响应是必不可少的。本文介绍了一种利用导电聚合物复合材料作为电极涂层来控制神经元在电极表面粘附的方法。电沉积的涂层进一步用感兴趣的生物分子（BOI）官能化，其中它们的表面浓度通过碳二亚胺化学的重复来控制。结果是电极表面促进了原代神经元的局部粘附，其密度可以通过添加的BOI层数的变化来定量控制。对于神经界面重要的是，发现BOI的附加层引起电阻抗的不显著增加，特别是当与用导电聚合物复合材料涂覆电极时阻抗的大幅下降相比时。
Tailoring cell response on an electrode is essential in the application of neural interfaces. In this paper a method of controlling neuron adhesion on the surface of an electrode was demonstrated using conducting polymer composite as an electrode coating. The electrodeposited coating was functionalized further with biomolecules-of-interest (BOI) with their surface concentration controlled via repetition of carbodiimide chemistry. The result was an electrode surface that promoted localized adhesion of primary neurons the density of which could be controlled quantitatively via changes in the number of layers of BOI added. Important to neural interfaces, it was found that additional layers of BOI caused an insignificant increase in the electrical impedance, especially when compared to the large drop in impedance upon coating of the electrode with conducting polymer composite.