Drug delivery systems for the treatment of diabetes mellitus: state of the art.
Drug delivery systems for the treatment of diabetes mellitus: state of the art.
复制标题
用于治疗糖尿病的药物输送系统：最先进的技术。
DOI：
10.2174/13816128113199990367
复制
发表时间：
2013
影响因子：
3.1
通讯作者：
S. Harding
中科院分区：
文献类型：
--
作者：
G. Adams;S. Harding
Arguably one of the greatest medical advancements in the 20th Century was the discovery of insulin. Physiologically, insulin is a potent hypoglycaemic agent, which is vital in order for plasma glucose levels to be maintained within the normal range of 4- 7mmol/L. Various attempts have been made in the production, purification, formulation and methods of delivery of insulin. Despite alternative routes being investigated, these routes have met with limited success. Although the pulmonary route offers potential for the delivery of polypeptide drugs due to its large surface area for insulin absorption, it has low bioavailability. Microencapsulation and nanoencapsulation exhibit potential progress in insulin delivery although delivery is at an early stage. In this Review, we discuss the structure of insulin and the physiological importance in addition to the injectable and non-injectable methods used. The currently available insulin therapies are presented and the clinical importance of such therapies.
