Synchronous endometrioid adenocarcinomas in the uterine cervix and corpus
Synchronous endometrioid adenocarcinomas in the uterine cervix and corpus
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子宫颈和子宫体同步子宫内膜样腺癌
DOI：
10.1111/jog.13049
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Fujiwara H
中科院分区：
文献类型：
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作者：
Obata T;Nakamura M;Mizumoto Y;Matsumoto T;Takakura M;Fujiwara H
多原发癌与单原发癌伴转移常常难以区分。在此，我们报告一个同时发生于子宫颈和子宫体的类性腺癌的病例。一名47岁女性主诉生殖器出血，术前诊断为宫颈腺癌伴子宫内膜病变。在手术治疗，两个独立的恶性病变轴承类腺癌确定在子宫颈和子宫腔。虽然这两个病变表达相同类型的人乳头瘤病毒（HPV）基因，16型，显微镜下观察不到连续性。此外，我们检测到肿瘤之间PTEN突变的关键差异，并最终诊断该病例为多原发癌。这是第一个报告，显示多个原发性子宫颈样腺癌同时发生在子宫颈和身体。考虑到这种情况的罕见性，HPV的共存表明它可能参与了类腺瘤的癌变过程。
It is frequently difficult to distinguish multiple primary carcinomas from single primary carcinoma with metastasis. Here, we report a case of synchronous endometrioid adenocarcinomas that independently occurred in the uterine cervix and corpus. A 47‐year‐old woman complaining of genital bleeding was preoperatively diagnosed with cervical adenocarcinoma with an endometrial lesion. On surgical treatment, two separate malignant lesions bearing endometrioid adenocarcinoma were identified in the uterine cervix and cavity. Although both lesions expressed the same type of human papillomavirus (HPV) gene, type 16, microscopic continuity was not observed. Furthermore, we detected a critical difference inPTENmutation between the tumors and finally diagnosed this case as multiple primary cancers. This is the first report to show multiple primary endometrioid adenocarcinomas simultaneously arising in the uterine cervix and corpus. Considering the rarity of this case, the coexistence of HPV suggests its possible involvement in the carcinogenesis of the endometrioid adenocarcinomas.