An electrophysiologic indication of auditory processing defects in autism.
An electrophysiologic indication of auditory processing defects in autism.
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自闭症听觉处理缺陷的电生理学指标。
DOI：
10.1016/0165-1781(80)90052-9
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发表时间：
1980
影响因子：
11.3
通讯作者：
Simson,R
中科院分区：
文献类型：
--
作者：
Novick,B;VaughanJr,HG;Kurtzberg,D;Simson,R
平均诱发电位（EP）点击，随机音高变化（信号），和随机删除的刺激在一个定期列车的音调进行了检查，在五个自闭症和五个正常儿童。其中1例孤独症患者脑干听觉诱发电位异常。早期皮层EP成分P60和N100在各组之间没有差异，而P200成分的皮层反应的点击，以及后期的积极成分（300）的音高变化和删除的刺激，是显着较小的自闭症受试者作为一个群体。此外，当P200和P300振幅在不同条件下对个体受试者进行平均时，这些成分在每个自闭症受试者中比任何正常受试者都要小。这些结果与自闭症中存在听觉缺陷的观点是一致的，自闭症有时可能涉及较低水平的神经传递，如脑干和听觉EP的异常所表现的，但更一致地表现在涉及刺激信息的登记和存储的处理的较高方面。这表明，严重的语言障碍，儿童孤独症可能是继发于高级听觉加工的基本缺陷。
Averaged evoked potentials (EPs) to clicks, random pitch changes (signals), and random deletions of stimuli within a regular train of tones were examined in five autistic and five normal children. Brainstem auditory EPs were abnormal in one of the autistic patients. The early cortical EP components P60 and N100 showed no differences across groups, whereas the P200 component of the cortical responses to clicks, as well as the late positive component (300) to the pitch changes and deleted stimuli, were significantly smaller in the autistic subjects as a group. Furthermore, when P200 and P300 amplitudes were averaged across conditions for the individual subjects, these components were smaller in every autistic subject than in any of the normal subjects. These results are consistent with the view that there are auditory defects in autism that may sometimes involve lower levels of neural transmission as manifested by abnormalities in the brainstem and auditory EP, but are more consistently manifest in higher aspects of processing that involve the registration and storage of stimulus information. It is suggested that the severe language disorder in childhood autism may be secondary to the basic deficits in higher auditory processing.