Age-related changes in collagen: the identification of reducible lysine-carbohydrate condensation products.
Age-related changes in collagen: the identification of reducible lysine-carbohydrate condensation products.
复制标题
胶原蛋白与年龄相关的变化：可还原赖氨酸-碳水化合物缩合产物的鉴定。
DOI：
10.1016/0006-291x(72)90346-4
复制
发表时间：
1972
影响因子：
3.1
通讯作者：
Allen J. Bailey
中科院分区：
文献类型：
--
作者：
S. Robins;Allen J. Bailey
在最近的出版物中（Bailey等人，1969年; Bailey和Shimokomaki，1971年），我们报道了几种类型胶原的可还原交联的年龄相关变化的研究。结果表明，在研究的所有组织中，所有这些分子间交联的量都随着年龄的增长而减少，推测是通过醛亚胺键转化为更稳定的不可还原形式。由于这些变化与生长速度成反比，因此该过程被认为是胶原蛋白成熟的重要步骤。此外，还发现其中两种可还原组分（称为组分A）随年龄增长而增加。这种现象不仅在所检查的不同组织中明显，而且在不同动物物种和人体中也明显。因此，Fr. A的增加似乎是衰老的一般特征，正是由于这个原因，对这些成分的性质进行了进一步的研究。本文简要介绍了从成熟牛皮中分离和鉴定它们的方法。
In recent publications (Bailey et al 1969; Bailey & Shimokomaki, 1971) we have reported studies of the age-related changes in the reducible cross-links of several types of collagens. It was shown that with all the tissues studied there was a decrease with age in the amounts of all these intermolecular cross-links, presumably by conversion of the aldimine bond to a more stable non-reducible form. Since these changes inversely paralleled the rate of growth, the process was considered an essential step in the maturation of collagen. In addition, it was found that two of the reducible components, designated Fraction A, increased with age. This phenomenon was apparent not only in the different tissues examined, but also in different species of animal and in man. Thus, an increase in Fr. A appears to be a general characteristic of ageing and it was for this reason that further studies of the nature of these components have been carried out. This paper briefly describes their isolation and identification from mature bovine skin.