Age- and performance-related differences in hippocampal contributions to episodic retrieval.
Age- and performance-related differences in hippocampal contributions to episodic retrieval.
复制标题
海马对情景检索的贡献与年龄和表现相关的差异。
DOI：
10.1016/j.dcn.2016.01.003
复制
发表时间：
2016
影响因子：
4.7
通讯作者：
Ghetti,Simona
中科院分区：
文献类型：
--
作者：
Sastre3rd,Marcos;Wendelken,Carter;Lee,JoshuaK;Bunge,SilviaA;Ghetti,Simona
本研究的目的是调查海马对情景记忆提取的贡献是否随年龄（8-9岁vs 10-11岁vs成人）、表现水平（高vs低）和海马子区域（头、体、尾）而变化。我们研究了从大样本（N= 126）中收集的情景检索过程中的fMRI数据。参与者判断刺激是否先前已被编码，如果是，则它与三个场景中的哪一个配对（即，来源判断）。对于8- 9岁的孩子以及表现不佳的10- 11岁的孩子，海马激活并不能可靠地区分正确回忆（正确来源），错误回忆（错误来源）或忘记项目的试验（错过试验）。对于高性能的10-11岁奥尔兹和低性能的成年人，观察到选择性海马激活正确的来源相对于不正确的来源和错过试验;这种效果在整个海马体中观察到。对于高性能的成年人，海马激活也区分正确和不正确的源trialsl，但仅在海马头部，这表明在成年人中的良好性能与更多的局灶性海马募集。因此，年龄和表现都是理解记忆和海马功能发展的重要因素。
The goal of the present study was to investigate whether hippocampal contribution to episodic memory retrieval varies as a function of age (8–9 versus 10–11 versus adults), performance levels (high versus low) and hippocampal sub-region (head, body, tail). We examined fMRI data collected during episodic retrieval from a large sample (N= 126). Participants judged whether a stimulus had been encoded previously, and, if so, which of three scenes it had been paired with (i.e., source judgment). For 8- to 9-years-olds as well as low-performing 10- to 11-year-olds, hippocampal activations did not reliably differentiate between trials on which item-scene associations were correctly recalled (correct source), incorrectly recalled (incorrect source), or trials on which the item was forgotten (miss trials). For high-performing 10–11-year olds and low-performing adults, selective hippocampal activation was observed for correct source relative to incorrect source and miss trials; this effect was observed across the entire hippocampus. For high-performing adults, hippocampal activation also distinguished between correct and incorrect source trialsl, but only in the hippocampal head, suggesting that good performance in adults is associated with more focal hippocampal recruitment. Thus, both age and performance are important factors for understanding the development of memory and hippocampal function.