Cardiac structure and function in response to a multi-stage marathon over 4486 km
Cardiac structure and function in response to a multi-stage marathon over 4486 km
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DOI：
10.1177/2047487319885035
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发表时间：
2019-10-26
影响因子：
8.3
通讯作者：
Schmidt-Trucksaess, Arno
中科院分区：
文献类型：
--
作者：
Klenk, Christopher;Brunner, Horst;Schmidt-Trucksaess, Arno
目的探讨2009年跨欧洲足球赛（TransEuropeFootRace 2009，TEFR）是否会导致心脏结构和功能的改变。方法对67名参赛运动员中的20名进行心脏磁共振成像（两名妇女; 3个时间点的平均值+/- SD年龄47.8 +/- 10.4岁）（在294 +/- 135 km（B）处进行基线扫描，在1735 +/- 86 km（T1）处进行二次扫描，在3370 +/- 90 km（T2）处进行三次扫描）。影像学检查包括左心室结构（质量）和功能（应变）评估。平行地，在静脉血液样品中测定心肌肌钙蛋白I、NT-pro-BNP、肌肉生长抑制素和GDF 11。10名运动员的子样本在比赛后8个月返回进行随访扫描。（B，158.5 ± 23.8 g; T1，165.1 ± 23.2 g; T2，167 ± 24.6 g; p < 0.001），尽管在其余的结构和功能参数中没有观察到显著变化。在第一个测量间隔期间，心肌肌钙蛋白I和NT-proBNP的血清浓度分别显著增加1.5倍和3.5倍，此后不再增加（心肌肌钙蛋白I，6.8 ± 3.1（B），16.9 ± 10.4（T1）和17.1 ± 9.7（T2）; NT-proBNP，30.3 +/- 22.8（B），135.9 +/- 177.5（T1）和111.2 +/- 87.3（T2）），而生长标志物肌生长抑制素和GDF 11没有变化。未观察到与功能参数的相关性，包括射血分数和两个心室的容积。随访扫描显示，减少到基线值（左心室质量157 +/- 19.3 g）。结论高运动引起的心脏容量负荷>2个月的超耐力跑的结果在生理结构的适应，没有不良的心血管重构的迹象。
Aims To investigate whether participation in the Trans Europe Foot Race 2009 (TEFR), an ultramarathon race held over 64 consecutive days and 4486 km, led to changes in cardiac structure and function.Methods Cardiac magnetic resonance imaging was performed in 20 of 67 participating runners (two women; mean +/- SD age 47.8 +/- 10.4 years) at three time points (baseline scan at 294 +/- 135 km (B), scan two at 1735 +/- 86 km (T1) and scan three at 3370 +/- 90 km (T2)) during the TEFR. Imaging included an assessment of left ventricular structure (mass) and function (strain). In parallel, cardiac troponin I, NT-pro-BNP, myostatin and GDF11 were determined in venous blood samples. A subsample of ten runners returned for a follow-up scan eight months after the race.Results Left ventricular mass increased significantly (B, 158.5 +/- 23.8 g; T1, 165.1 +/- 23.2 g; T2, 167 +/- 24.6 g; p < 0.001) over the course of the race, although no significant change was seen in the remaining structural and functional parameters. Serum concentrations of cardiac troponin I and NT-proBNP significantly increased 1.5 - and 3.5-fold, respectively, during the first measurement interval, with no further increase thereafter (cardiac troponin I, 6.8 +/- 3.1 (B), 16.9 +/- 10.4 (T1) and 17.1 +/- 9.7 (T2); NT-proBNP, 30.3 +/- 22.8 (B), 135.9 +/- 177.5 (T1) and 111.2 +/- 87.3 (T2)), whereas the growth markers myostatin and GDF11 did not change. No association was observed with functional parameters, including the ejection fraction and the volume of both ventricles. The follow-up scans showed a reduction to baseline values (left ventricular mass 157 +/- 19.3 g).Conclusions High exercise-induced cardiac volume load for >2 months in ultra-endurance runners results in a physiological structural adaptation with no sign of adverse cardiovascular remodelling.