Relationship between Ras pathways and cell cycle control.
Relationship between Ras pathways and cell cycle control.
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DOI：
10.1007/978-1-4615-4253-7_1
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Ewen
中科院分区：
文献类型：
--
作者：
M. Ewen
细胞繁殖的两个主要事件（基因组复制和细胞分裂）的有序执行是细胞周期进展的特征。培养的细胞可以通过改变细胞外条件在循环和非循环状态之间切换，并且一个关键的细胞控制机制主持这一决定的概念，其时间位置被称为限制点，已经成为研究细胞外促有丝分裂信号传导如何影响细胞周期以影响增殖的焦点。这篇综述试图涵盖Ras介导的促有丝分裂信号转导的不同途径，影响限制点控制。
The ordered execution of the two main events of cellular reproduction, duplication of the genome and cell division, characterize progression through the cell cycle. Cultured cells can be switched between cycling and non-cycling states by alteration of extracellular conditions and the notion that a critical cellular control mechanism presides on this decision, whose temporal location is known as the restriction point, has become the focus for the study of how extracellular mitogenic signalling impinges upon the cell cycle to influence proliferation. This review attempts to cover the disparate pathways of Ras-mediated mitogenic signal transduction that impact upon restriction point control.