MMN responsivity to manipulations of frequency and duration deviants in chronic, clozapine-treated schizophrenia patients
MMN responsivity to manipulations of frequency and duration deviants in chronic, clozapine-treated schizophrenia patients
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DOI：
10.1016/j.schres.2010.11.028
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发表时间：
2011-03-01
影响因子：
4.5
通讯作者：
Knott, Verner J.
中科院分区：
文献类型：
--
作者：
Horton, Jemeen;Millar, Anne;Knott, Verner J.
失配负波(MMN)对精神分裂症患者异常感觉过程的事件相关电位(ERP)探测在听觉变化检测方面显示出障碍，但对导致这种缺陷的声学特征的了解并不完整。声音刺激的持续时间和频率特性的变化会导致精神分裂症患者MMN的减少，但目前尚不清楚这种反应性降低是否与声音频率的更微妙变化有关。用氯氮平治疗的19例健康对照和21例慢性精神分裂症患者为研究对象，对5%、10%、20%的声调频率变化和声调时程变化进行了MMN检测。与对照组相比，患者表现出对所有频率变化的幅度降低和潜伏期缩短，并且随着音调持续时间的增加和减少而幅度减弱。氯氮平剂量与MMN呈正相关，剂量增加与频率-MMN波幅(10%Delta f、20%Delta f)呈正相关，与时程-MMN波幅及潜伏期呈负相关。这些数据支持精神分裂症听觉感觉异常的公认发现，并强调了MMN对相对较小的听觉变化检测缺陷的敏感性，这些缺陷可能是慢性精神分裂症的特征。(C)2010爱思唯尔B.V.保留所有权利。
Event-related potential (ERP) probing of abnormal sensory processes in schizophrenia with the mismatch negativity (MMN) has shown impairments in auditory change detection, but knowledge of the acoustic features leading to this deficit is incomplete. Changes in the duration and frequency properties of sound stimuli result in diminished MMNs in schizophrenia but it is unclear as to whether this reduced responsiveness is seen with more subtle changes in sound frequency. In a sample of 19 healthy controls and 21 patients with chronic schizophrenia treated with clozapine, MMN was assessed in response to tone frequency changes of 5%, 10% and 20%, and to tone duration changes. Patients exhibited reduced amplitudes and shorter latencies than controls to all frequency changes, and attenuated amplitudes to tone duration increments and decrements. Clozapine dose was related to MMN, with increasing dose being positively associated with frequency-MMN amplitudes (10% Delta f, 20% Delta f) and negatively associated with the amplitude and latency of duration-MMNs. These data support the well-established findings of auditory sensory abnormality in schizophrenia and underscore the sensitivity of MMN to relatively small auditory change detection deficits that may appear to characterize chronic schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.