Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection.
Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection.
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与致命的埃博拉病毒感染相关的干扰素 (IFN)-γ、IFN-α、白细胞介素 (IL)-2、IL-10 和肿瘤坏死因子-α 水平显着升高。
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
C. Peters
中科院分区：
文献类型：
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作者：
F. Villinger;P. Rollin;S. Brar;N. Chikkala;J. Winter;J. Sundstrom;S. Zaki;R. Swanepoel;A. Ansari;C. Peters
免疫机制在埃博拉出血热（EHF）发病机制中的作用仍有待阐明。在这份报告中，将死于 EHF 的患者的血清细胞因子水平与康复患者和对照患者的血清细胞因子水平进行了比较。与康复或对照患者相比，在所有致命性 EHF 病例的连续血清样本中观察到干扰素 (IFN)-γ 水平显着升高 (>100 pg/mL)。在致命性 EHF 病例中，白细胞介素 (IL)-2、IL-10、肿瘤坏死因子 (TNF)-α 和 IFN-α 的血清水平也显着升高；然而，它们具有更大程度的可变性。 IL-4 和 IL-6 的血清水平没有差异。对同一患者的血凝块进行 mRNA 定量显示，EHF 患者样本中 TNF-α 和 IFN-α 的水平相对较高。综上所述，这些结果表明，高度的免疫激活伴随并可能导致 EHF 患者的致命结果。
The role of immune mechanisms in the pathogenesis of Ebola hemorrhagic fever (EHF) remains to be elucidated. In this report, the serum cytokine levels of patients who died of EHF were compared with those of patients who recovered and those of control patients. A marked elevation of interferon (IFN)-gamma levels (>100 pg/mL) was observed in sequential serum samples from all fatal EHF cases compared with patients who recovered or controls. Markedly elevated serum levels of interleukin (IL)-2, IL-10, tumor necrosis factor (TNF)-alpha, and IFN-alpha were also noted in fatal EHF cases; however, they had a greater degree of variability. No differences were noted in serum levels of IL-4 and IL-6. mRNA quantitation from blood clots of the same patients showed relatively elevated levels of TNF-alpha and IFN-alpha in samples from EHF patients. Taken together, these results suggest that a high degree of immune activation accompanies and potentially contributes to a fatal outcome in EHF patients.