HEXOSE-6-PHOSPHATE DEHYDROGENASE - DISTRIBUTION IN RAT TISSUES AND EFFECT OF DIET, AGE AND STEROIDS
HEXOSE-6-PHOSPHATE DEHYDROGENASE - DISTRIBUTION IN RAT TISSUES AND EFFECT OF DIET, AGE AND STEROIDS
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DOI：
10.1016/0003-9861(70)90118-9
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发表时间：
1970-01-01
影响因子：
3.9
通讯作者：
BEUTLER, E
中科院分区：
文献类型：
--
作者：
MANDULA, B;SRIVASTAVA, SK;BEUTLER, E
己糖-6-磷酸脱氢酶是一种微粒体酶，它利用NAD或NADP作为氢受体氧化葡萄糖-6-磷酸、半乳糖-6-磷酸、2-脱氧葡萄糖-6-磷酸和葡萄糖。研究了其在大鼠组织中的分布；这种酶存在于肝脏、肾上腺、脾脏、肾脏、心脏、肺、臀肌、睾丸、卵巢、精囊、前列腺、子宫和肠道中。脑组织和乳腺未检出酶。己糖-6-磷酸脱氢酶不受各种已知抑制葡萄糖-6-磷酸脱氢酶的类固醇的抑制。同样，饲喂含有68%半乳糖、葡萄糖或果糖的日粮不会改变大鼠肝脏中己糖-6- p脱氢酶的活性。肝脏己糖-6- p脱氢酶活性在出生前迅速升高，然后逐渐下降至成人水平。己糖-6- p脱氢酶似乎可能是混合功能氧化酶系统中还原吡啶核苷酸的来源，但缺乏其在代谢中的作用的明确证据。
Hexose-6-P dehydrogenase is a microsomal enzyme which oxidizes glucose-6-P, galactose-6-P, 2-deoxy-glucose-6-P, and glucose using either NAD or NADP as hydrogen acceptor. Its distribution was studied in rat tissues; the enzyme was found in liver, adrenals, spleen, kidney, heart, lungs, gluteal muscle, testes, ovaries, seminal vesicles, prostate, uterus, and intestine. No enzyme was detected in the brain and mammary gland.Hexose-6-P dehydrogenase is not inhibited by various steroids which are known to inhibit glucose-6-P dehydrogenase. Also, feeding of a diet containing 68% galactose, glucose, or fructose does not alter the activity of hexose-6-P dehydrogenase in rat liver. Liver hexose-6-P dehydrogenase activity increased rapidly before birth, and then declined gradually to adult levels.It appears possible the hexose-6-P dehydrogenase serves as a source of reduced pyridine nucleotides for mixed-function oxidase systems, but definitive evidence for its role in metabolism is lacking.