A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids.
A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids.
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DOI：
10.3390/s8010370
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发表时间：
2008-01-21
期刊：
影响因子：
--
通讯作者：
Arnau A
中科院分区：
文献类型：
--
作者：
Arnau A
自20多年前首次将AT-Cut石英晶体作为传感器应用于溶液中以来，所谓的石英晶体微天平(QCM)传感器在生物传感器、生物分子相互作用分析、细菌在特定界面上的黏附研究、病原体和微生物检测、聚合物膜-生物分子或细胞-基质相互作用的研究、免疫传感器以及在流体和聚合物表征和电化学应用等领域的广泛应用中，正在成为一种很好的替代分析方法。对这一分析方法的适当评价需要认识到所涉及的不同步骤，并意识到它们的重要性和局限性。QCM系统涉及的第一步是针对具体应用对传感器进行准确和适当的表征。使用与溶液接触的压电式传感器对其行为有很大影响，必须使用适当的电子接口才能进行适当的传感器表征。在过去的25年里，已经实施了基于不同原理和技术的系统。特定应用的接口选择很重要，必须了解其局限性，意识到其适用性，并避免在解释结果时可能出现的错误传播。本文全面介绍了AT-Cut石英晶体微天平在溶液中应用的不同技术，这些技术基于以下原理：网络或阻抗分析仪、衰减法、振荡器和锁定技术。详细讨论了基于振荡器和锁相技术的电子接口，并描述了不同的配置，因为这些技术最常用于检测溶液中的分析物，以及那些需要快速传感器响应的应用。
From the first applications of AT-cut quartz crystals as sensors in solutions more than 20 years ago, the so-called quartz crystal microbalance (QCM) sensor is becoming into a good alternative analytical method in a great deal of applications such as biosensors, analysis of biomolecular interactions, study of bacterial adhesion at specific interfaces, pathogen and microorganism detection, study of polymer film-biomolecule or cell-substrate interactions, immunosensors and an extensive use in fluids and polymer characterization and electrochemical applications among others. The appropriate evaluation of this analytical method requires recognizing the different steps involved and to be conscious of their importance and limitations. The first step involved in a QCM system is the accurate and appropriate characterization of the sensor in relation to the specific application. The use of the piezoelectric sensor in contact with solutions strongly affects its behavior and appropriate electronic interfaces must be used for an adequate sensor characterization. Systems based on different principles and techniques have been implemented during the last 25 years. The interface selection for the specific application is important and its limitations must be known to be conscious of its suitability, and for avoiding the possible error propagation in the interpretation of results. This article presents a comprehensive overview of the different techniques used for AT-cut quartz crystal microbalance in in-solution applications, which are based on the following principles: network or impedance analyzers, decay methods, oscillators and lock-in techniques. The electronic interfaces based on oscillators and phase-locked techniques are treated in detail, with the description of different configurations, since these techniques are the most used in applications for detection of analytes in solutions, and in those where a fast sensor response is necessary.
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影响因子：
8.4
作者：
AUGE, J;HAUPTMANN, P;ROSLER, S
通讯作者：
ROSLER, S
影响因子：
8.4
作者：
Chagnard, C;Gilbert, P;Paul, DW
通讯作者：
Paul, DW
DOI：
10.1109/58.911746
发表时间：
2001-03-01
影响因子：
3.6
作者：
Arnau, A;Sogorb, T;Jiménez, Y
通讯作者：
Jiménez, Y
影响因子：
1.6
作者：
Arnau, A;Sogorb, T;Jiménez, Y
通讯作者：
Jiménez, Y
影响因子：
1.6
作者：
Arnau, A;Sogorb, T;Jiménez, Y
通讯作者：
Jiménez, Y