The Phage Proteomic Tree: a genome-based taxonomy for phage
The Phage Proteomic Tree: a genome-based taxonomy for phage
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DOI：
10.1128/jb.184.16.4529-4535.2002
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发表时间：
2002-08-01
影响因子：
3.2
通讯作者：
Edwards, R
中科院分区：
文献类型：
--
作者：
Rohwer, F;Edwards, R
在生物圈中有大约10（31）个噬菌体，使它们成为地球上最丰富的生物实体。尽管噬菌体数量众多，无处不在，但人们对噬菌体生物多样性、细菌地理学或细菌发生学知之甚少。信息是有限的，部分原因是目前的ICTV分类系统是基于培养噬菌体和测量游离病毒粒子的物理参数。以前没有建立基于序列的噬菌体分类系统。我们在这里提出的“噬菌体蛋白质组树”，这是基于105个完全测序的噬菌体基因组的整体相似性。噬菌体蛋白质组学树将噬菌体相对于其近邻和分析中包括的所有其他噬菌体放置。该方法将噬菌体分组为分类群，预测噬菌体生物学的几个方面，并突出显示可用于监测噬菌体生物多样性的遗传标记。我们建议，噬菌体蛋白质组树可以作为一个基于基因组的噬菌体分类系统的基础。
There are similar to10(31) phage in the biosphere, making them the most abundant biological entities on the planet. Despite their great numbers and ubiquitous presence, very little is known about phage biodiversity, biogeography, or phylogeny. Information is limited, in part, because the current ICTV taxonomical system is based on culturing phage and measuring physical parameters of the free virion. No sequence-based taxonomic systems have previously been established for phage. We present here the "Phage Proteomic Tree," which is based on the overall similarity of 105 completely sequenced phage genomes. The Phage Proteomic Tree places phage relative to both their near neighbors and all other phage included in the analysis. This method groups phage into taxa that predicts several aspects of phage biology and highlights genetic markers that can be used for monitoring phage biodiversity. We propose that the Phage Proteomic Tree be used as the basis of a genome-based taxonomical system for phage.