Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging
Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging
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DOI：
10.1016/j.biomaterials.2009.04.014
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发表时间：
2009-08-01
期刊：
影响因子：
14
通讯作者：
Fahmy, Tarek M.
中科院分区：
文献类型：
--
作者：
Criscione, Jason M.;Le, Bonaire L.;Fahmy, Tarek M.
树枝状大分子是具有明确分支化学结构的纳米级大分子。对这些结构的结构和功能的控制使材料科学和生物医学应用取得了许多进展。虽然树枝状聚合物是通过简单重复步骤的迭代直接合成的，但通过共价合成方法产生许多生物医学应用所需的更大、更复杂的结构一直是具有挑战性的。在这里，我们展示了一个自发的自组装的聚（酰胺胺）树枝状聚合物成复杂的纳米级和微观颗粒的组成树枝状聚合物亚基的部分结晶后。这些致密颗粒表现出对低外部pH的刺激诱导的响应，这导致它们随着时间的推移而分解，从而能够控制包封剂的释放。此外，我们表明，这些组件提供了足够高的氟自旋密度，使其在体内的特定位点的积累，通过F-19磁共振成像（F-19 MRI）检测。氟化树枝状聚合物为基础的微粒提出了新的功能和重要的新兴生物医学应用的各种能力。(C)2009爱思唯尔有限公司保留所有权利。
Dendrimers are nanoscale macromolecules with well-defined branching chemical structures. Control over the architecture and function of these structures has enabled many advances in materials science and biomedical applications. Though dendrimers are directly synthesized by iteration of simple repetitive steps, generation of the larger, more complex structures required for many biomedical applications by covalent synthetic methods has been challenging. Here we demonstrate a spontaneous self-assembly of poly(amidoamine) dendrimers into complex nanoscopic and microscopic particulates following partial fluorination of the constituent dendrimer subunits. These dense particulates exhibit a stimulus-induced response to low external pH that causes their disassembly over time, enabling controlled release of encapsulated agents. In addition, we show that these assemblies offer a sufficiently high density of fluorine spins to enable detection of their site-specific accumulation in vivo by F-19 magnetic resonance imaging (F-19 MRI). Fluorinated dendrimer-based particulates present new features and capabilities important for a wide variety of emerging biomedical applications. (C) 2009 Elsevier Ltd. All rights reserved.