Bischler-Napieralski Synthesis of 6-Alkynyl Phenanthridines Based on Tf2O-Promoted Electrophilic Activation of N-Aryl-2-propynamides.
Bischler-Napieralski Synthesis of 6-Alkynyl Phenanthridines Based on Tf2O-Promoted Electrophilic Activation of N-Aryl-2-propynamides.
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DOI：
10.1021/acs.joc.1c01543
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
L. Shan;Hongchen Li;L. Min;Yunxiang Weng;Xinyan Wang-;Yuefei Hu
中科院分区：
文献类型：
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作者：
L. Shan;Hongchen Li;L. Min;Yunxiang Weng;Xinyan Wang-;Yuefei Hu
提出了一种合成6-炔基菲啶的有效方法。该方法提供了第一个例子，在Bischler-Napieralski反应中使用2-丙酰胺作为底物，并在有机合成中生成作为新的活性中间体的炔基三氟化腈。
An efficient method for the synthesis of 6-alkynyl phenanthridines was developed. The method offered the first example to use 2-propynamides as substrates in the Bischler-Napieralski reaction and to create alkynylnitrilium triflates as new active intermediates in organic synthesis.