Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country
Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country
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DOI：
10.1007/s10195-014-0322-y
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发表时间：
2015-03-01
影响因子：
2.8
通讯作者：
Kazakos, Konstantinos
中科院分区：
文献类型：
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作者：
Goula, Thomais;Kouskoukis, Alexandros;Kazakos, Konstantinos
背景维生素D在骨矿化、重塑和维持中起重要作用，因此其缺乏可能与骨关节炎（OA）的发病机制有关。在计划进行关节置换术的膝关节或髋关节OA患者中评价维生素D状况。人体测量参数，如性别，年龄和体重指数对维生素D水平的影响也进行了研究。这项研究是在一个地中海国家（希腊）。材料和方法，我们纳入了164例膝关节或髋关节OA计划在这项研究中的关节置换术。采用放射免疫分析法测定25-羟维生素D（Vitamin D）水平，并与手术前1周进行比较。结果本组患者中维生素D缺乏者占81.7%，维生素D不足者占15.2%。只有3%的患者维生素D充足.维生素D水平和男性gender. Conclusion之间有显着的正相关性，这些研究结果表明，一个大的百分比的维生素D缺乏症患者膝关节或髋关节OA，这是意想不到的，考虑到高的年度日照在北方希腊。许多其他可能诱发OA的因素应予以考虑。维生素D补充剂治疗是否可以为这些患者提供有益的效果，以及这种治疗应该开始的疾病阶段仍然是进一步科学研究的问题。
Background Vitamin D plays an important role in bone mineralization, remodeling, and maintenance and therefore its deficiency may be implicated in the pathogenesis of osteoarthritis (OA). Vitamin D status was evaluated in patients with knee or hip OA scheduled for joint replacement. The impact of anthropometric parameters such as gender, age, and body mass index on vitamin D levels was also examined. The study was conducted in a Mediterranean country (Greece).Materials and methods We included 164 patients with knee or hip OA scheduled for joint replacement in this study. Serum levels of 25-hydroxyvitamin D (vitamin D) were measured in routine blood samples taken from the patients at their pre-admission visit, a week before the operation, using radioimmunoassay.Results The majority of patients were vitamin D deficient (81.7 %); 15.2 % of them were vitamin D insufficient (hypovitaminosis). Only 3 % of patients were vitamin D sufficient. There was a significantly positive association between vitamin D levels and male gender.Conclusion These findings indicate a large percentage of vitamin D deficient patients with knee or hip OA, which is unexpected considering the high annual insolation in northern Greece. Many other possible predisposing factors for OA should be taken into consideration. Whether treatment with vitamin D supplements may provide beneficial effects to these patients and the stage of disease in which this treatment should commence remains an issue for further scientific investigation.