Factors affecting self-reported chemical intolerance: A five-year follow-up study in Japan
Factors affecting self-reported chemical intolerance: A five-year follow-up study in Japan
复制标题
DOI：
10.1016/j.jpsychores.2019.01.001
复制
发表时间：
2019-03-01
影响因子：
4.7
通讯作者：
Kunugita, Naoki
中科院分区：
文献类型：
--
作者：
Azuma, Kenichi;Uchiyama, Iwao;Kunugita, Naoki
目的：化学不耐受（CI）已成为工业化国家的一个强烈的公共卫生问题。日本化学品不耐受（JCI）研究于2012年1月进行，以基于人群抽样的7245名成人队列作为基线。本研究的目的是调查的改善和发展的CI从5年的随访study.Methods：从7245队列，735人CI（例），并随机选择1750名对照组无CI，以匹配性别和年龄的情况下和对照组的因素。自我报告的问卷调查的两组的主题，以获得信息CI的状态;病史;医疗，生活方式，或物理干预;生活状况或职业的变化;和心身state.Results：在随访期间，共有909人回答。5年后，观察到67.7%的病例组CI改善。对照组6.7%的患者报告了CI状态。多元Logistic回归分析显示，基线特应性皮炎和消极的心身状态，包括易怒，疲劳，焦虑，抑郁情绪，和躯体症状与CI的发展显着相关的控制。适当的体力活动和保持有规律的生活方式，包括饮食或睡眠，在过去三年的随访期的显着因素，改善CI的情况group.Conclusions：确保适当的体力活动和有规律的生活方式，而不是改善物理环境，导致改善CI。稳定的心身状态是预防脑梗死的关键。
Objective: Chemical intolerance (CI) has become a strong public health concern in industrialized countries. The Japanese Chemical Intolerance (JCI) study was conducted in January 2012 with a cohort of 7245 adults from population-based sampling as the baseline. The aim of the present study was to investigate the factors involved in the improvement and development of CI from the five-year follow-up study.Methods: From the 7245 cohort, 735 persons with CI (case) were identified, and 1750 controls without CI were randomly selected to match gender and age for case and control groups. Self-reported questionnaires were administered to the subjects of the two groups to obtain information on status of CI; medical history; medical, lifestyle, or physical interventions; changes in living situation or occupation; and psychosomatic states.Results: A total of 909 individuals responded during the follow-up period. After five years, improvement in CI was observed in 67.7% of the case group. Status of CI was reported in 6.7% of the control group. Multiple logistic regression analyses revealed that baseline atopic dermatitis and negative psychosomatic states including irritability, fatigue, anxiety, depressed mood, and somatic symptoms were significantly associated with development of CI in controls. Appropriate physical activity and maintaining a regular lifestyle including diet or sleep during the last three years of the follow-up period were significant factors for improvement of CI in the case group.Conclusions: Ensuring appropriate physical activity and regular lifestyle rather than improving physical environment lead to improvement of CI. Stable psychosomatic state is essential for preventing CI.