Efficacy of Fluoride Compounds and Stannous Chloride as Erosion Inhibitors in Dentine
Efficacy of Fluoride Compounds and Stannous Chloride as Erosion Inhibitors in Dentine
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DOI：
10.1159/000314671
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发表时间：
2010-01-01
期刊：
影响因子：
4.2
通讯作者：
Schlueter, N.
中科院分区：
文献类型：
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作者：
Ganss, C.;Lussi, A.;Schlueter, N.
本研究的目的是评估不同的氟化物和一种锡化合物在复杂的牙本质侵蚀病理组织学背景下的抗侵蚀作用，特别强调有机部分的作用。样品进行了两个实验，包括侵蚀性酸攻击（0.05摩尔柠檬酸，pH 2.3; 6 x 2 min/天）和应用（6 x 2 min/天）以下供试品溶液：SnCl（2）（815 ppm Sn）、NaF（250 ppm F）、SnF（2）（250 ppm F，809 ppm Sn）、氟化胺（AmF，250 ppm F）、AmF/NaF（250 ppm F）和AmF/SnF（2）（250 ppm F，409 ppm Sn）。在实验结束时（实验1）或在整个实验过程中（实验2）连续地酶促除去脱矿物质的有机部分。在10个实验天后，通过轮廓测定法确定组织损失。在实验1中，在对照组中发现最高的侵蚀性组织损失（仅侵蚀）;含AmF和NaF的溶液使组织损失减少约60%，SnCl（2）、AmF/SnF（2）和SnF（2）的减少分别为52%、74%和89%。在实验2中，损失值通常显著更高，并且测试溶液之间的差异更加明显。含AmF和NaF制剂的组织损失减少率为12 - 34%，SnCl（2）、AmF/SnF（2）和SnF（2）分别为11、67和78%。含氟化亚锡的溶液在牙本质中显示出有希望的抗侵蚀作用。这两个实验的显著不同的结果表明，重新考虑目前的方法，研究抗蚀剂在牙本质的策略。版权所有（C）2010 S. Karger AG，巴塞尔
The aim of this study was to evaluate the anti-erosive effects of different fluoride compounds and one tin compound in the context of the complex pathohistology of dentine erosion, with particular emphasis on the role of the organic portion. Samples were subjected to two experiments including erosive acid attacks (0.05 molar citric acid, pH 2.3; 6 x 2 min/day) and applications (6 x 2 min/day) of the following test solutions: SnCl(2) (815 ppm Sn), NaF (250 ppm F), SnF(2) (250 ppm F, 809 ppm Sn), amine fluoride (AmF,250 ppm F), AmF/NaF (250 ppm F), and AmF/SnF(2) (250 ppm F, 409 ppm Sn). The demineralised organic fraction was enzymatically removed either at the end of the experiment (experiment 1) or continuously throughout the experiment (experiment 2). Tissue loss was determined profilometrically after 10 experimental days. In experiment 1, the highest erosive tissue loss was found in the control group (erosion only); the AmF- and NaF-containing solutions reduced tissue loss by about 60%, reductions for SnCl(2), AmF/SnF(2), and SnF(2) were 52, 74 and 89%, respectively. In experiment 2, loss values generally were significantly higher, and the differences between the test solutions were much more distinct. Reduction of tissue loss was between 12 and 34% for the AmF- and NaF-containing preparations, and 11, 67 and 78% for SnCl(2), AmF/SnF(2), and SnF(2), respectively. Stannous fluoride-containing solutions revealed promising anti-erosive effects in dentine. The strikingly different outcomes in the two experiments suggest reconsidering current methodologies for investigating anti-erosive strategies in dentine. Copyright (C) 2010 S. Karger AG, Basel