Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip.
Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip.
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DOI：
10.1016/j.canlet.2015.12.003
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发表时间：
2016-09-28
期刊：
影响因子：
9.7
通讯作者：
Korc M
中科院分区：
文献类型：
--
作者：
Han B;Qu C;Park K;Konieczny SF;Korc M
靶向递送的目的是选择性地将药物分配到靶向肿瘤组织而不是健康组织。这可以通过最大化抗癌药物的功效但最小化其毒性来解决许多临床挑战。然而，复杂的肿瘤微环境构成了各种障碍，阻碍了药物和药物递送系统的运输。非常需要允许对这些复杂环境进行系统研究的新肿瘤模型，以提供可靠的测试床来开发用于靶向递送的药物递送系统。最近，研究工作已经产生了新的体外肿瘤模型，即所谓的芯片上肿瘤微环境，其概括了肿瘤微环境的某些特征。这些新模型显示出优于其他传统肿瘤模型的优势，并有可能加速药物发现并实现精准药物。然而，进一步的研究是必要的，以克服其局限性，并正确地解释从这些模型中获得的数据。本文就肿瘤靶向给药过程中肿瘤微环境的主要特征进行了讨论，并对体外药物转运模型系统的研究现状和面临的挑战进行了综述。
Targeted delivery aims to selectively distribute drugs to targeted tumor tissue but not to healthy tissue. This can address many of clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicines. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery was discussed, and the current status and challenges for developing in vitro transport model systems was reviewed.