Imaging Local Diffusive Dynamics Using Diffusion Exchange Spectroscopy MRI

Imaging Local Diffusive Dynamics Using Diffusion Exchange Spectroscopy MRI
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DOI:
10.1103/physrevlett.118.158003
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发表时间:
2017-04-12
影响因子:
8.6
通讯作者:
Basser, Peter J.
Basser, Peter J.
中科院分区:
物理与天体物理1区
文献类型:
--
作者:
Benjamini, Dan;Komlosh, Michal E.;Basser, Peter J.

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水在微环境之间的运动是软物质和多孔介质物理学中的一个核心挑战。扩散交换光谱(DEXSY)是一种强有力的二维核磁共振方法来测量这种交换,但它很少使用,因为它的扫描时间长的要求。此外,它从来没有与磁共振成像(MRI)相结合。使用概率论,我们大大减少了所需的数据,使DEXSYMRI首次可行。实验是在具有限制和自由水交换室的复合神经组织模型上进行的。
The movement of water between microenvironments presents a central challenge in the physics of soft matter and porous media. Diffusion exchange spectroscopy (DEXSY) is a powerful 2D nuclear magnetic resonancemethod formeasuring such exchange, yet it is rarely used because of its long scan time requirements. Moreover, it has never been combined withmagnetic resonance imaging (MRI). Using probability theory, we vastly reduce the required data, making DEXSYMRI feasible for the first time. Experiments are performed on a composite nerve tissue phantom with restricted and free water-exchanging compartments.