The role of stem cells in limb regeneration.
The role of stem cells in limb regeneration.
复制标题
干细胞在肢体再生中的作用。
DOI：
10.1080/15476278.2016.1163463
复制
发表时间：
2016
期刊：
影响因子：
2.3
通讯作者：
Wan,DerrickC
中科院分区：
文献类型：
--
作者：
Zielins,ElizabethR;Ransom,RyanC;Leavitt,TrippE;Longaker,MichaelT;Wan,DerrickC
肢体再生是一个复杂而迷人的过程，在某种程度上观察到许多动物物种，虽然看到在有尾目两栖动物的整体。通过形成形态上均匀的中间体芽基来完成，科学家们长期以来一直试图定义使功能性附属物再生的细胞成分。今天，我们知道芽基由来自各种组织的多能祖细胞组成，并以谱系限制的方式促进肢体组织再生。通过继续剖析干细胞在肢体再生中的作用，我们希望有一天能调节人类对截肢的反应，并促进工作替代品的再生。
Limb regeneration is a complex yet fascinating process observed to some extent in many animal species, though seen in its entirety in urodele amphibians. Accomplished by formation of a morphologically uniform intermediate, the blastema, scientists have long attempted to define the cellular constituents that enable regrowth of a functional appendage. Today, we know that the blastema consists of a variety of multipotent progenitor cells originating from a variety of tissues, and which contribute to limb tissue regeneration in a lineage-restricted manner. By continuing to dissect the role of stem cells in limb regeneration, we can hope to one day modulate the human response to limb amputation and facilitate regrowth of a working replacement.