A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity
A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity
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DOI：
10.1038/sj.mp.4001716
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发表时间：
2005-09-01
影响因子：
11
通讯作者：
Hariri, AR
中科院分区：
文献类型：
--
作者：
Brown, SM;Peet, E;Hariri, AR
最近的研究表明，新发现的色氨酸羟化酶基因（TPH2）的第二种异构体优先参与神经元血清素的限速合成。人类TPH2基因（hTPH2）的遗传变异与体外酶活性的改变以及情绪障碍风险的增加有关。在这里，我们提供了第一个体内证据，证明hTPH2的一个相对频繁的调节变体（G(-844)T）会影响杏仁核的反应性，杏仁核是一种对情绪行为的产生和调节至关重要的神经结构。
Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.