Antagonist muscle co-activation during straight walking and its relation to kinematics: Insight from young, elderly and Parkinson's disease
Antagonist muscle co-activation during straight walking and its relation to kinematics: Insight from young, elderly and Parkinson's disease
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DOI：
10.1016/j.brainres.2012.03.033
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发表时间：
2012-05-21
期刊：
影响因子：
2.9
通讯作者：
Cudeiro, Javier
中科院分区：
文献类型：
--
作者：
Arias, Pablo;Espinosa, Nelson;Cudeiro, Javier
行走过程中下肢拮抗肌协同激活的增加似乎是对衰老生理变化的适应过程，以获得关节的稳定性。在健康受试者中，当步态加快时，协同激活指数（CAI）增加，这一事实似乎加强了这一观点。少数关于帕金森病（PD）患者拮抗剂共激活的报道表明，他们比健康老年人具有更大的共激活，支持CAI在步态中的稳定作用的观点，因为姿势不稳定是PD的主要特征。然而，也有报道称，在PD或正常老年人中，当速度增加时，CAI也会降低。这就质疑了在加速过程中共活化在稳定化中的作用。在本研究中，我们分析了健康受试者（年轻人和老年人）和PD患者（有和没有步态冻结，FOG）的步态，以更好地了解共激活与步态运动学之间的关系，并深入了解PD中FOG相关的病理变化。我们采用多元线性回归模型研究了小腿肌肉CAI与速度和节奏的关系。我们的结果表明，对于所有感兴趣的群体，由于高度可变性，共同激活与步态运动学之间的关系很差，质疑该指数的解释价值。(C) 2012 Elsevier B.V.版权所有
Increased antagonist muscle co-activation of the lower limb during walking seems to be an adaptive process to the physiological changes of aging, in order to gain joint stability. In the healthy subjects this view seems to be reinforced by the fact that the co-activation index (CAI) increases when the gait is faster. The few reports on antagonist co-activation in Parkinson's disease (PD) patients indicate that they have larger co-activation than the healthy elderly, supporting the idea of the stabilization role of CAI during gait, as postural instability is a cardinal feature of PD. However it has also been reported that there is a reduction of the CAI when increasing velocity in PD or normal elderly. This questions the role of co-activation in stabilization during increased velocity. In this study we have analyzed the gait of healthy subjects (young and elderly), and PD patients (with and without freezing of gait, FOG) in order to better understand the relation between co-activation and gait kinematics, and to gain insight into the pathological changes associated with FOG in PD. We used Multiple Linear Regression models to study the relationship in shank muscles between CAI, velocity and cadence. Our results indicate that, for all groups of interest, the relationship between co-activation and the kinematics of gait is poor, due to the high degree of variability, questioning the explanatory value of the index. (C) 2012 Elsevier B.V. All rights reserved.