Electrophoretic Mobility of Lipoprotein Nanoparticle Mimics.
Electrophoretic Mobility of Lipoprotein Nanoparticle Mimics.
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脂蛋白纳米颗粒模拟物的电泳迁移率。
DOI：
10.1109/nano.2011.6144448
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Reed,ScottM
中科院分区：
文献类型：
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作者：
Wang,MinS;Reed,ScottM
脂蛋白颗粒（Lipoprotein particles，LPPs）是一种生物纳米颗粒，其生理作用受其大小的影响很大。LP的四个主要类别是：极低密度脂蛋白、中密度脂蛋白、低密度脂蛋白（LDL）和高密度脂蛋白。由于小密度LDL的优势与冠状动脉疾病（CAD）和糖尿病的风险增加相关，因此LPP谱可用于预测代谢风险因素。高度可调的LPP模拟物可以使用纳米颗粒合成，以仔细控制尺寸，脂质组成和表面电荷，以促进CAD中LPP的研究。在这里，我们使用直径在10-50 nm之间的金纳米颗粒设计了LPP模拟物。我们测量了这些LPP模拟物的迁移率和zeta电位，并表明每个模拟物具有不同的电动力学性质，并且是静电稳定的。
Lipoprotein particles (LPPs) are biological nanoparticles whose physiological roles are greatly influenced by their sizes. The four major classes of LP are: very low density lipoprotein, intermediate density lipoprotein, low density lipoprotein (LDL) and high density lipoprotein. Since the predominance of small, dense LDLs is associated with increased risk of coronary artery disease (CAD) and diabetes mellitus, LPP profiling can be used to predict metabolic risk factors. Highly tunable LPP mimics can be synthesized using nanoparticles to carefully control for size, lipid composition and surface charge to facilitate the study LPPs in CAD. Here, we engineered LPP mimics using gold nanoparticles between 10-50 nm in diameters. We measured the mobility and zeta potential of these LPP mimics and showed that each mimics have distinct electrokinetic properties and are electrostatically stable.