Stereoselective synthesis of (-)-malyngolide, (+)-malyngolide and (+)-tanikolide using ring-closing metathesis
Stereoselective synthesis of (-)-malyngolide, (+)-malyngolide and (+)-tanikolide using ring-closing metathesis
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DOI：
10.1016/s0040-4020(02)01594-6
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发表时间：
2003-02-03
期刊：
影响因子：
2.1
通讯作者：
Marco, JA
中科院分区：
文献类型：
--
作者：
Carda, M;Rodríguez, S;Marco, JA
描述了天然存在的δ-内酯（+）-taniklide和（-）-malyngolide以及后者的非天然（+）-对映体的立体选择性合成。这些合成中的每一个的关键步骤是有机金属试剂的立体选择性加成到α-含氧酮和烯烃闭环复分解。(C)2003爱思唯尔科技有限公司版权所有。
The stereoselective syntheses of the naturally occurring delta-lactones (+)-tanikolide and (-)-malyngolide as well as of the unnatural (+)-enantiomer of the latter are described. Key steps in each of these syntheses were stereoselective additions of organometallic reagents to a-oxygenated ketones and olefin ring-closing metatheses. (C) 2003 Elsevier Science Ltd. All rights reserved.