Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.
复制标题
自噬和化疗耐药：癌症治疗的一个有前途的治疗靶点
DOI：
10.1038/cddis.2013.350
复制
发表时间：
2013-10-10
影响因子：
9
通讯作者：
Pan, H.
中科院分区：
文献类型：
--
作者：
Sui, X.;Chen, R.;Wang, Z.;Huang, Z.;Kong, N.;Zhang, M.;Han, W.;Lou, F.;Yang, J.;Zhang, Q.;Wang, X.;He, C.;Pan, H.
诱导细胞死亡和抑制细胞存活是癌症治疗的主要原则。化疗药物的耐药性是肿瘤学中的一个主要问题，限制了抗癌药物的有效性。导致耐药性的因素有很多，包括宿主因素、癌细胞中特定的基因或表观遗传改变等。虽然癌细胞在微环境中对抗癌药物产生耐药性的各种机制已经被很好地阐明，但如何规避这种耐药性以提高抗癌疗效仍有待确定。自噬是一种重要的动态平衡细胞循环机制，它试图通过分解过量或不必要的蛋白质以及受损或老化的细胞器来维持/恢复代谢动态平衡，是应对代谢和治疗应激的关键因素。最近，一些研究表明，自噬是癌症治疗的一个潜在靶点，治疗后诱导自噬可以被视为具有延长生命或延长生命的作用，这有助于这些药物的抗癌效果和耐药性。因此，了解自噬的新功能可能会使我们开发出一种有前景的治疗策略，以增强化疗的效果，改善癌症患者的临床结果。
Induction of cell death and inhibition of cell survival are the main principles of cancer therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which limits the effectiveness of anticancer drugs. A variety of factors contribute to drug resistance, including host factors, specific genetic or epigenetic alterations in the cancer cells and so on. Although various mechanisms by which cancer cells become resistant to anticancer drugs in the microenvironment have been well elucidated, how to circumvent this resistance to improve anticancer efficacy remains to be defined. Autophagy, an important homeostatic cellular recycling mechanism, is now emerging as a crucial player in response to metabolic and therapeutic stresses, which attempts to maintain/restore metabolic homeostasis through the catabolic lysis of excessive or unnecessary proteins and injured or aged organelles. Recently, several studies have shown that autophagy constitutes a potential target for cancer therapy and the induction of autophagy in response to therapeutics can be viewed as having a prodeath or a prosurvival role, which contributes to the anticancer efficacy of these drugs as well as drug resistance. Thus, understanding the novel function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancer patients.
登录
查看更多内容
影响因子：
9
作者：
Dando, I.;Donadelli, M.;Costanzo, C.;Pozza, E. Dalla;D'Alessandro, A.;Zolla, L.;Palmieri, M.
通讯作者：
Palmieri, M.
全基因组 SNP 标记揭示中国和西方猪的遗传多样性、连锁不平衡和选择特征
影响因子：
3.7
作者：
Ai H;Huang L;Ren J
通讯作者：
Ren J
影响因子：
6.4
作者：
Cloonan, Suzanne M.;Williams, David Clive
通讯作者：
Williams, David Clive
肝细胞癌中的自噬激活通过活性氧调节促进奥沙利铂的耐受性
影响因子：
11.5
作者：
Ding, Zhen-Bin;Hui, Bo;Fan, Jia
通讯作者：
Fan, Jia
Bcl-2 同源结构域 3 模拟棉酚在癌细胞中诱导 Beclin 1 依赖性和 Beclin 1 独立的细胞保护性自噬
影响因子：
4.8
作者：
Gao, Ping;Bauvy, Chantal;Mehrpour, Maryam
通讯作者：
Mehrpour, Maryam