Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin.
Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin.
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DOI：
10.5402/2012/431859
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Mimata H
中科院分区：
文献类型：
--
作者：
Mori K;Noguchi M;Sumino Y;Sato F;Mimata H
目标.研究降钙素原（PCT）是否可用于检测血液透析（HD）和降钙素（CT）升高患者的细菌感染。方法.这项前瞻性研究包括42名男性和34名女性接受HD治疗。感染组包括15例确诊为细菌感染的患者;其他61例患者被指定为非感染组。在HD开始时测定血清C反应蛋白（CRP）、白细胞介素（IL）-6、白色细胞（WBC）计数、未成熟中性粒细胞/总中性粒细胞（I/T）比值、CT，并在HD开始时和HD后测定血清PCT水平。结果两组的平均CT值均明显高于非慢性肾脏病组。CRP、IL-6、WBC、I/T比值、PCT和CT在感染组和非感染组之间的值显著较高。受试者工作特征曲线下面积PCT值为0.921，显著高于CRP（0.853; P < 0.01）、IL-6（0.739; P < 0.01）、WBC（0.692; P < 0.01）和I/T比值（0.584; P < 0.01）。结论. PCT是HD和CT增加患者细菌感染的有用标志物。应在HD前测定PCT水平。
Objectives. To investigate whether procalcitonin (PCT) could be useful for detecting bacterial infections in patients on hemodialysis (HD) and with increased calcitonin (CT). Methods. This prospective study included 42 males and 34 females on HD. The infection group consisted of 15 patients with proven bacterial infections; the other 61 patients were designated as the noninfection group. Serum C-reactive protein (CRP), interleukin (IL)-6, white blood cell (WBC) count, immature and total neutrophil (I/T) ratio, and CT were measured at the beginning of HD, and serum PCT levels at the beginning of HD and after HD. Results. The mean CT level in the both groups was apparently higher than that of nonchronic kidney disease. Significantly higher values between the infection and noninfection groups were seen for CRP, IL-6, WBC, I/T ratio, PCT, and CT. The PCT value of the area under the receiver operating characteristic curve was 0.921, which was significantly higher than the values for CRP (0.853; P < 0.01), IL-6 (0.739; P < 0.01), WBC (0.692; P < 0.01), and I/T ratio (0.584; P < 0.01). Conclusions. PCT was useful marker of bacterial infection in patients on HD and with increased CT. PCT levels should be determined before HD.