Redistribution of spatial representation in the hippocampus of aged rats performing a spatial memory task.
Redistribution of spatial representation in the hippocampus of aged rats performing a spatial memory task.
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DOI：
10.1037//0735-7044.110.5.1006
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发表时间：
1996-10
影响因子：
1.9
通讯作者：
S. Mizumori;A. Lavoie;Anjali Kalyani
中科院分区：
文献类型：
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作者：
S. Mizumori;A. Lavoie;Anjali Kalyani
年轻和年老的大鼠在相同或不同的环境中根据强迫选择进行迷宫，然后进行空间记忆程序。当在同一个房间中测试时，老年大鼠学习空间记忆任务的速度较慢，但在不同的房间中则不然。对这种结果的一种解释是，尽管老年大鼠学习新规则的速度与年轻大鼠一样快，但它们对旧规则和熟悉的空间信息的灵活性较差。渐近线表现期间的选择准确性受损表明老年大鼠对试验独特信息的处理不良。海马CA1区和门细胞的空间相关性随任务需求而变化：老年大鼠的CA1区细胞显示出更多的空间选择性场所，而门细胞在空间记忆中显示出更多的弥漫性位置编码，而不是强迫选择，测试。这种表征重组可能反映了海马对年龄相关神经生物学变化的代偿反应。
Young and old rats performed on a maze according to a forced-choice and then a spatial memory procedure either in the same or a different environment. Aged rats were slower to learn the spatial memory task when tested in the same, but not in a different, room. One interpretation of this pattern of results is that although old rats learn new rules as quickly as young rats, they show less flexibility with old rules and familiar spatial information. Impaired choice accuracy during asymptote performance suggests poor processing of trial-unique information by old rats. Spatial correlates of hippocampal CA1 and hilar cells varied with task demand: CA1 cells of aged rats showed more spatially selective place fields, whereas hilar cells showed more diffuse location coding during spatial memory, and not forced-choice, tests. Such representational reorganization may reflect a compensatory response to age-related neurobiological changes in hippocampus.