Application of Place-Based Methods to Lung Transplant Medicine.
Application of Place-Based Methods to Lung Transplant Medicine.
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DOI：
10.3390/ijerph19127355
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发表时间：
2022-06-15
影响因子：
--
通讯作者：
Curtis, Jacqueline
中科院分区：
文献类型：
--
作者：
Tsuang, Wayne M.;MacMurdo, Maeve;Curtis, Jacqueline
对于患有致命肺部疾病的患者，肺移植是一种越来越常见的挽救生命的疗法，但这种干预措施有一个关键的局限性，因为移植后的中位生存期仅为5.5年。尽管基于地点的因素对肺健康有深远的影响，但在LT接受者中尚未对此进行严格的调查-由于终生需要日常维持生命的免疫抑制药物，这是一个脆弱的群体。移植医学在时间和地点方面也存在长期的方法学空白；这一空白可以通过地理空间科学来填补。作为探索性分析的一部分，我们研究了我们中心两年内移植的受者。主要结果是移植后第一年内至少发生了一次排斥反应。我们发现，受助人平均有1.7个独特的住址，这是一个适度的搬迁率。肺拒绝与人口普查中主要代表人数不足的少数群体或以社会脆弱性指数衡量的英语不是主要语言的人口普查有关。人口普查区域可能在衡量和解决移植方面的地理差异方面发挥重要作用。在未来的范式中，患者空间数据可能成为实时临床护理的一个组成部分，以帮助个性化风险分层和个性化医疗保健提供。
Lung transplantation is an increasingly common lifesaving therapy for patients with fatal lung diseases, but this intervention has a critical limitation as median survival after LT is merely 5.5 years. Despite the profound impact of place-based factors on lung health, this has not been rigorously investigated in LT recipients—a vulnerable population due to the lifelong need for daily life-sustaining immunosuppression medications. There have also been longstanding methodological gaps in transplant medicine where both time and place have not been measured; gaps which could be filled by the geospatial sciences. As part of an exploratory analysis, we studied recipients transplanted at our center over a two-year period. The main outcome was at least one episode of rejection within the first year after transplant. We found recipients averaged 1.7 unique residential addresses, a modest relocation rate. Lung rejection was associated with census tracts of predominantly underrepresented minorities or where English was not the primary language as measured by the social vulnerability index. Census tracts likely play an important role in measuring and addressing geographic disparities in transplantation. In a future paradigm, patient spatial data could become an integrated part of real time clinical care to aid in personalized risk stratification and personalized delivery of healthcare.
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影响因子：
8.5
作者：
Laranjo, Liliana;Rodrigues, David;Boavida, Jose Manuel
通讯作者：
Boavida, Jose Manuel
影响因子：
5.4
作者：
Flowerdew, Robin;Manley, David J.;Sabel, Clive E.
通讯作者：
Sabel, Clive E.
DOI：
10.1016/j.healun.2020.07.009
发表时间：
2020-10
期刊：
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子：
--
作者：
Chambers DC;Zuckermann A;Cherikh WS;Harhay MO;Hayes D Jr;Hsich E;Khush KK;Potena L;Sadavarte A;Singh TP;Stehlik J;International Society for Heart and Lung Transplantation
通讯作者：
International Society for Heart and Lung Transplantation
影响因子：
17.1
作者：
Bharat A;Querrey M;Markov NS;Kim S;Kurihara C;Garza-Castillon R;Manerikar A;Shilatifard A;Tomic R;Politanska Y;Abdala-Valencia H;Yeldandi AV;Lomasney JW;Misharin AV;Budinger GRS
通讯作者：
Budinger GRS
影响因子：
120.7
作者：
Dwyer-Lindgren, Laura;Bertozzi-Villa, Amelia;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.